(2R,3R,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate

Base Information

Chemical Name:(2R,3R,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate
CAS No.:1421359-40-1
Molecular Formula:C₂₉H₅₁O₇PSi
Molecular Weight:570.779
Hs Code.:

Synonyms:(2R,3R,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate

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Technology Process of (2R,3R,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate

There total 7 articles about (2R,3R,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 3095-95-2
diethylphosphonoacetic acid

: 1421359-32-1
(2R,3R,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-ol

: 1421359-40-1
(2R,3R,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jo302440a

Reference yield:

: 1421359-27-4
(2R,3S,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-ol

: 1421359-40-1
(2R,3R,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 0 - 20 °C

2: potassium carbonate / methanol / 16 h / 20 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 20 °C

With dmap; di-isopropyl azodicarboxylate; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo302440a

Reference yield:

: 565454-94-6
(S)-(4-(benzyloxy)-3-methyl-2-methylenebutyl)trimethylsilane

: 1421359-40-1
(2R,3R,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tin(IV) chloride / dichloromethane / 1 h / -78 °C

1.2: 0.83 h / -78 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 0 - 20 °C

3.1: potassium carbonate / methanol / 16 h / 20 °C

4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 20 °C

With dmap; di-isopropyl azodicarboxylate; tin(IV) chloride; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo302440a