Butanoic acid, 2-(cyclopentylamino)-, methyl ester, (2R)-

Base Information

• Chemical Name: Butanoic acid, 2-(cyclopentylamino)-, methyl ester, (2R)-
• CAS No.: 755039-52-2
• Molecular Formula: C10H19NO2
• Molecular Weight: 185.26
• Mol file: 755039-52-2.mol

Synonyms:Butanoic acid, 2-(cyclopentylamino)-, methyl ester, (2R)-

Chemical Property of Butanoic acid, 2-(cyclopentylamino)-, methyl ester, (2R)-

Chemical Property:

• PSA: 38.33000
• LogP: 1.86110
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

methyl2-mmvvmqbutanoate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 2-(cyclopentylamino)-, methyl ester, (2R)-

There total 3 articles about Butanoic acid, 2-(cyclopentylamino)-, methyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-2-aminobutyric acid methyl ester hydrochloride (85774-09-0) + cyclopentanone (120-92-3) → (R)-methyl 2-(cyclopentylamino)butanoate (755039-52-2)

Guidance literature:

With sodium acetate; sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1002/cbic.201500535

Reference yield: 97.0%

(R)-2-Aminobuttersaeure-methylester (74645-03-7) + cyclopentanone (120-92-3) → (R)-methyl 2-(cyclopentylamino)butanoate (755039-52-2)

Guidance literature:

With sodium acetate; sodium tris(acetoxy)borohydride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201103273

Reference yield:

→ (R)-methyl 2-(cyclopentylamino)butanoate (755039-52-2)

Guidance literature:

upstream raw materials:

(R)-2-Aminobuttersaeure-methylester

cyclopentanone

(R)-2-aminobutyric acid methyl ester hydrochloride

Downstream raw materials:

1-tert-butyl 4-[(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzoyl)amino]piperidine-1-carboxylate

Refernces

• 1、 -. "Compound containing methotrexate structure as well as preparation method and application thereof". Paragraph 0071-0074. . Retrieved 2021/11/14.
• 2、 Hu, Rong,Liu, Zhi-Hao,Shi, Yao-Jie,Wang, Ning-Yu,Wang, Wan-Li,Xiao, Kun-Jie,Xu, Ying,Yu, Luo-Ting,Zhu, Yong-Xia,Zuo, Wei-Qiong. "Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors". . . Retrieved 2020/02/26.