Technology Process of [3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol
There total 4 articles about [3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-fluoro-1-(phenylmethoxycarbonylamino)-4-(1H-1,2,4-triazol-1-yl)benzene;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
(R)-glycidyl butyrate;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 24h;
Further stages.;
DOI:10.1021/jm990373e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 72 percent / K2HPO4 / dimethylsulfoxide / 18 h / 90 °C
2.1: H2 / Pd/C / tetrahydrofuran / 18 h / 2327.23 Torr
3.1: 2.6 g / NaHCO3 / tetrahydrofuran / 48 h / -20 - 20 °C
4.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C
4.2: 57 percent / tetrahydrofuran / 24 h / -78 - 20 °C
With
dipotassium hydrogenphosphate; hydrogen; sodium hydrogencarbonate; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran; dimethyl sulfoxide;
1.1: Substitution / 2.1: Reduction / 3.1: Acylation / 4.1: Metallation / 4.2: Ring cleavage;
DOI:10.1021/jm990373e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: H2 / Pd/C / tetrahydrofuran / 18 h / 2327.23 Torr
2.1: 2.6 g / NaHCO3 / tetrahydrofuran / 48 h / -20 - 20 °C
3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C
3.2: 57 percent / tetrahydrofuran / 24 h / -78 - 20 °C
With
hydrogen; sodium hydrogencarbonate; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran;
1.1: Reduction / 2.1: Acylation / 3.1: Metallation / 3.2: Ring cleavage;
DOI:10.1021/jm990373e
