[3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol

Base Information

Chemical Name:[3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol
CAS No.:226220-38-8
Molecular Formula:C₁₂H₁₁FN₄O₃
Molecular Weight:278.243
Hs Code.:

Synonyms:[3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol

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Chemical Property of [3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol

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Technology Process of [3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol

There total 4 articles about [3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 60456-26-0
(R)-glycidyl butyrate

: 181997-14-8
3-fluoro-1-(phenylmethoxycarbonylamino)-4-(1H-1,2,4-triazol-1-yl)benzene

: 226220-38-8
[3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol

Guidance literature:: 3-fluoro-1-(phenylmethoxycarbonylamino)-4-(1H-1,2,4-triazol-1-yl)benzene; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

(R)-glycidyl butyrate; In tetrahydrofuran; at -78 - 20 ℃; for 24h; Further stages.;
DOI:10.1021/jm990373e

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 226220-38-8
[3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 72 percent / K₂HPO₄ / dimethylsulfoxide / 18 h / 90 °C

2.1: H₂ / Pd/C / tetrahydrofuran / 18 h / 2327.23 Torr

3.1: 2.6 g / NaHCO₃ / tetrahydrofuran / 48 h / -20 - 20 °C

4.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

4.2: 57 percent / tetrahydrofuran / 24 h / -78 - 20 °C

With dipotassium hydrogenphosphate; hydrogen; sodium hydrogencarbonate; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dimethyl sulfoxide; 1.1: Substitution / 2.1: Reduction / 3.1: Acylation / 4.1: Metallation / 4.2: Ring cleavage;
DOI:10.1021/jm990373e

Reference yield:

: 182060-01-1
3-fluoro-1-nitro-4-(1H-1,2,4-triazol-1-yl)benzene

: 226220-38-8
[3-[3-fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / Pd/C / tetrahydrofuran / 18 h / 2327.23 Torr

2.1: 2.6 g / NaHCO₃ / tetrahydrofuran / 48 h / -20 - 20 °C

3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

3.2: 57 percent / tetrahydrofuran / 24 h / -78 - 20 °C

With hydrogen; sodium hydrogencarbonate; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1.1: Reduction / 2.1: Acylation / 3.1: Metallation / 3.2: Ring cleavage;
DOI:10.1021/jm990373e