5-pyridin-4-yl-1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazole

Base Information

Chemical Name:5-pyridin-4-yl-1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazole
CAS No.:1345687-98-0
Molecular Formula:C₂₅H₂₅N₃O₃
Molecular Weight:415.492
Hs Code.:

Synonyms:5-pyridin-4-yl-1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazole

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Chemical Property of 5-pyridin-4-yl-1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazole

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Technology Process of 5-pyridin-4-yl-1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazole

There total 7 articles about 5-pyridin-4-yl-1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1345687-97-9
1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazol-5-yl trifluoromethanesulfonate

: 1692-15-5
4-pyridylboronic acid

: 1345687-98-0
5-pyridin-4-yl-1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 1h; Inert atmosphere;

Reference yield:

: 610-81-1
4-hydroxy-2-nitroaniline

: 1345687-98-0
5-pyridin-4-yl-1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazole

Guidance literature:: Multi-step reaction with 7 steps

1: 1H-imidazole / dichloromethane / 20 °C / Cooling with ice

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 0.17 h / 110 °C / Inert atmosphere

3: hydrogen; palladium(II) hydroxide / ethanol / 2 h / 20 °C

4: ytterbium trifluoromethanesulfonate / 0.17 h / 90 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

6: pyridine / dichloromethane / -20 - -10 °C

7: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 1 h / 80 °C / Inert atmosphere

With pyridine; 1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ytterbium trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; palladium(II) hydroxide; potassium carbonate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; sodium t-butanolate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1345687-91-3
4-{ [tert-butyl(dimethyl)silyl]oxy}-N¹-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}benzene-1,2-diamine

: 1345687-98-0
5-pyridin-4-yl-1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: ytterbium trifluoromethanesulfonate / 0.17 h / 90 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3: pyridine / dichloromethane / -20 - -10 °C

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 1 h / 80 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ytterbium trifluoromethanesulfonate; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;