8-<<3-(p-isobutoxycarbonyl)phenoxy-2-oxo-propyl>thio> adenosine

Base Information

• Chemical Name: 8-<<3-(p-isobutoxycarbonyl)phenoxy-2-oxo-propyl>thio> adenosine
• CAS No.: 147538-91-8
• Molecular Formula: C₂₄H₂₉N₅O₈S
• Molecular Weight: 547.589
• Mol file: 147538-91-8.mol

Synonyms:8-<<3-(p-isobutoxycarbonyl)phenoxy-2-oxo-propyl>thio> adenosine

Chemical Property of 8-<<3-(p-isobutoxycarbonyl)phenoxy-2-oxo-propyl>thio> adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-<<3-(p-isobutoxycarbonyl)phenoxy-2-oxo-propyl>thio> adenosine

There total 5 articles about 8-<<3-(p-isobutoxycarbonyl)phenoxy-2-oxo-propyl>thio> adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,6-dimethylpyridine (108-48-5) + isobutyl p-(3-bromo-2-oxo)-propyloxy benzoate + 8-mercaptoadenosine (3001-45-4) → 8-<<3-(p-isobutoxycarbonyl)phenoxy-2-oxo-propyl>thio> adenosine (147538-91-8)

Guidance literature:

With sodium hydrogencarbonate; In diethyl ether; ethanol; water; ethyl acetate;

Reference yield: 85.0%

8-mercaptoadenosine (3001-45-4) + 1-bromo-3-<(4-isobutoxycarbonyl)phenoxy>propan-2-one (147539-04-6) → 8-<<3-(p-isobutoxycarbonyl)phenoxy-2-oxo-propyl>thio> adenosine (147538-91-8)

Guidance literature:

With 2,6-dimethylpyridine; In ethanol; for 3h; Heating;

DOI:10.1016/0223-5234(94)90098-1

Reference yield:

isobutyl 4-hydroxybenzoate (4247-02-3) → 8-<<3-(p-isobutoxycarbonyl)phenoxy-2-oxo-propyl>thio> adenosine (147538-91-8)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / butan-2-one / Heating

2: HBr, AcOH

3: CrO₃, H₂SO₄

4: 85 percent / 2,6-lutidine / ethanol / 3 h / Heating

With 2,6-dimethylpyridine; chromium(VI) oxide; sulfuric acid; hydrogen bromide; potassium carbonate; acetic acid; In ethanol; butanone;

DOI:10.1016/0223-5234(94)90098-1

upstream raw materials:

8-mercaptoadenosine

1-bromo-3-<(4-isobutoxycarbonyl)phenoxy>propan-2-one

isobutyl 4-hydroxybenzoate

3-(4-isobutoxycarbonyl)phenoxy-1-bromoacetone

Downstream raw materials:

8-[3-[(p-isobutyloxycarbonyl)-phenoxy]-2-hydroxyimino-propylthio]-adenosine