C₄₉H₅₃ClN₂O₁₁

Base Information

• Chemical Name: C₄₉H₅₃ClN₂O₁₁
• CAS No.: 1613149-73-7
• Molecular Formula: C₄₉H₅₃ClN₂O₁₁
• Molecular Weight: 881.42
• Mol file: 1613149-73-7.mol

Synonyms:C₄₉H₅₃ClN₂O₁₁

Chemical Property of C₄₉H₅₃ClN₂O₁₁

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₅₃ClN₂O₁₁

There total 13 articles about C₄₉H₅₃ClN₂O₁₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(2S,3S,4R,5R,6R)-2-(3-(bromomethyl)-4-chlorophenyl)-3,4,5-tris(methoxymethoxy)-6-((methoxymethoxy)methyl)-tetrahydro-2H-pyran (1334297-71-0) + C34H33BN2O4 (1356964-49-2) → C49H53ClN2O11 (1613149-73-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.04.036

Reference yield:

(3R,4S,5S,6R)-2-(3-((tert-butyldiphenylsilyloxy)methyl)-4-chlorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol (866605-96-1) → C49H53ClN2O11 (1613149-73-7)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / dichloromethane / 24 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

4: triethylamine / toluene; ethyl acetate / 2 h / 0 °C

5: lithium bromide / acetone / 1 h / 0 - 20 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

With triethylsilane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium bromide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 6: |Suzuki Coupling;

DOI:10.1016/j.bmc.2014.04.036

Reference yield:

C22H35ClO12S → C49H53ClN2O11 (1613149-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium bromide / acetone / 1 h / 0 - 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; lithium bromide; In water; N,N-dimethyl-formamide; acetone; 2: |Suzuki Coupling;

DOI:10.1016/j.bmc.2014.04.036

upstream raw materials:

(3R,4S,5S,6R)-2-(3-((tert-butyldiphenylsilyloxy)methyl)-4-chlorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

4-bromo-aniline

N-(4-bromophenyl)cyanamide

C₁₀H₉BrN₂O₂

Downstream raw materials:

1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-tritylimidazolidine-2,4-dione