C₂₂H₃₂N₅O₈P

Base Information

• Chemical Name: C₂₂H₃₂N₅O₈P
• CAS No.: 1403250-92-9
• Molecular Formula: C₂₂H₃₂N₅O₈P
• Molecular Weight: 525.499
• Mol file: 1403250-92-9.mol

Synonyms:C₂₂H₃₂N₅O₈P

Chemical Property of C₂₂H₃₂N₅O₈P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₃₂N₅O₈P

There total 9 articles about C₂₂H₃₂N₅O₈P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester (1256490-52-4,1627824-09-2) + C10H16N4O4 (1403249-61-5) → C22H32N5O8P (1403250-92-9)

Guidance literature:

C₁₀H₁₆N₄O₄; With tert-butylmagnesium chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.25h;

(S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; for 16h;

With methanol; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

Reference yield:

N4-acetyl-1-<3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-pentofuran-2-ulosyl>cytosine (140859-16-1) → C22H32N5O8P (1403250-92-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.33 h / 20 °C

1.2: 4 h / 0 - 20 °C

2.1: 4-toluenesulfonyl azide / 1,1,2,2-tetramethyl-1,2-ethanediamino-N,N'-bis(3,5-di-tert-butylsalicylidene)-cobalt(II) / 0.08 h / 20 °C

2.2: 0.53 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

4.1: ammonia; methanol / 3 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

6.1: tert-butylmagnesium chloride / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 0.25 h / 20 °C

6.2: 16 h

With methanol; 4-toluenesulfonyl azide; tert-butylmagnesium chloride; tetrabutyl ammonium fluoride; ammonia; hydrogen; potassium hexamethylsilazane; 1,1,2,2-tetramethyl-1,2-ethanediamino-N,N'-bis(3,5-di-tert-butylsalicylidene)-cobalt(II); palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; 1.2: Wittig Reaction;

Reference yield:

CYTIDINE (65-46-3) → C22H32N5O8P (1403250-92-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: pyridine / 15.25 h / 20 °C

2.1: ethanol / 3 h / 65 °C

2.2: 0 °C

3.1: Dess-Martin periodane / dichloromethane / 15 h / 0 - 20 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.33 h / 20 °C

4.2: 4 h / 0 - 20 °C

5.1: 4-toluenesulfonyl azide / 1,1,2,2-tetramethyl-1,2-ethanediamino-N,N'-bis(3,5-di-tert-butylsalicylidene)-cobalt(II) / 0.08 h / 20 °C

5.2: 0.53 h

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

7.1: ammonia; methanol / 3 h / 20 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

9.1: tert-butylmagnesium chloride / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 0.25 h / 20 °C

9.2: 16 h

With pyridine; methanol; 4-toluenesulfonyl azide; tert-butylmagnesium chloride; tetrabutyl ammonium fluoride; ammonia; hydrogen; potassium hexamethylsilazane; Dess-Martin periodane; 1,1,2,2-tetramethyl-1,2-ethanediamino-N,N'-bis(3,5-di-tert-butylsalicylidene)-cobalt(II); palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; 4.2: Wittig Reaction;

upstream raw materials:

CYTIDINE

3',5'-O-[(1,1,3,3-tetraisopropyl)-1,3-disiloxanediyl]cytidine

N₄-acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

N⁴-acetyl-1-<3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-pentofuran-2-ulosyl>cytosine