C₄₃H₄₄ClF₃N₂O₁₄S

Base Information

Chemical Name:C₄₃H₄₄ClF₃N₂O₁₄S
CAS No.:1414948-93-8
Molecular Formula:C₄₃H₄₄ClF₃N₂O₁₄S
Molecular Weight:937.342
Hs Code.:

C<sub>43</sub>H<sub>44</sub>ClF<sub>3</sub>N<sub>2</sub>O<sub>14</sub>S

Synonyms:C₄₃H₄₄ClF₃N₂O₁₄S

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Chemical Property of C₄₃H₄₄ClF₃N₂O₁₄S

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Technology Process of C₄₃H₄₄ClF₃N₂O₁₄S

There total 18 articles about C₄₃H₄₄ClF₃N₂O₁₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1414948-74-5
(1R,3S)-2-chloroethyl 8-(benzyloxy)-1-{(3R,5R)-5-[6-(benzyloxy)-7-hydroxybenzo[d][1,3]dioxol-4-yl]-6-oxomorpholin-3-yl}-3-(dimethoxymethyl)-7-methoxy-6-methyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1414948-93-8
C₄₃H₄₄ClF₃N₂O₁₄S

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1055/s-0032-1316579

Reference yield:

: 1414948-46-1
(S)-5-(2-amino-3,3-dimethoxypropyl)-2-methoxy-3-methylphenol

: 1414948-93-8
C₄₃H₄₄ClF₃N₂O₁₄S

Guidance literature:: Multi-step reaction with 8 steps

1: formic acid; sodium sulfate / dichloromethane / 24 h / 0 - 20 °C

2: potassium carbonate / acetone / 41.5 h / 0 - 20 °C

3: pyridine / dichloromethane / 1 h / 0 - 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol / acetonitrile / 2 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 23.5 h / 0 - 20 °C

6: N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C

7: trifluoroacetic acid / dichloromethane / 0.42 h / 0 °C

8: pyridine / dichloromethane / 0.5 h / 0 °C

With pyridine; N-Bromosuccinimide; formic acid; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium sulfate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2-hydroxyethanethiol; In dichloromethane; acetone; acetonitrile; 1: |Pictet-Spengler Synthesis;
DOI:10.1055/s-0032-1316579

Reference yield:

: 575444-12-1
3-(benzyloxy)-4-methoxy-5-methylbenzaldehyde

: 1414948-93-8
C₄₃H₄₄ClF₃N₂O₁₄S

Guidance literature:: Multi-step reaction with 17 steps

1.1: N,N,N',N'-tetramethylguanidine / dichloromethane / 48 h / 20 °C

2.1: (+)-1,2-bis-[(2S,5S)-2,5-diethylphospholano]benzene (1,5-cycloctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen / ethyl acetate / 72 h / 50 °C / 25858.1 Torr

3.1: methanol; acetyl chloride / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 0 - 20 °C

7.1: diisobutylaluminium hydride / toluene / 1.5 h / -78 °C / Inert atmosphere

7.2: 1 h / 20 °C

8.1: water; toluene-4-sulfonic acid / methanol / 1.5 h / 20 °C / Reflux

9.1: 10% Pd/C; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

10.1: formic acid; sodium sulfate / dichloromethane / 24 h / 0 - 20 °C

11.1: potassium carbonate / acetone / 41.5 h / 0 - 20 °C

12.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

13.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol / acetonitrile / 2 h / 0 - 20 °C

14.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 23.5 h / 0 - 20 °C

15.1: N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C

16.1: trifluoroacetic acid / dichloromethane / 0.42 h / 0 °C

17.1: pyridine / dichloromethane / 0.5 h / 0 °C

With pyridine; methanol; N-Bromosuccinimide; formic acid; (+)-1,2-bis-[(2S,5S)-2,5-diethylphospholano]benzene (1,5-cycloctadiene)rhodium(I) trifluoromethanesulfonate; 10% Pd/C; water; hydrogen; diisobutylaluminium hydride; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; trifluoroacetic acid; 2-hydroxyethanethiol; lithium hydroxide; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetone; toluene; acetonitrile; 1.1: |Horner-Wadsworth-Emmons Olefination / 10.1: |Pictet-Spengler Synthesis;
DOI:10.1055/s-0032-1316579