N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide

Base Information

• Chemical Name: N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide
• CAS No.: 476352-17-7
• Molecular Formula: C₁₉H₁₉NO₅
• Molecular Weight: 341.364
• Mol file: 476352-17-7.mol

Synonyms:N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide

Chemical Property of N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide

There total 3 articles about N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)glyoxylamide (476352-08-6) → N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide (476352-17-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 1h;

DOI:10.1016/S0040-4020(02)00472-6

Reference yield:

4,6-dimethoxy-3-phenylbenzofuran (108838-36-4) → N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide (476352-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 45 °C

2: 550 mg / CH₂Cl₂; H₂O

3: 99 percent / NaBH₄ / methanol / 1 h

With sodium tetrahydroborate; In methanol; dichloromethane; water;

DOI:10.1016/S0040-4020(02)00472-6

Reference yield:

4,6-dimethoxy-3-phenylbenzofuran-2-glyoxyloyl chloride → N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide (476352-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 550 mg / CH₂Cl₂; H₂O

2: 99 percent / NaBH₄ / methanol / 1 h

With sodium tetrahydroborate; In methanol; dichloromethane; water;

DOI:10.1016/S0040-4020(02)00472-6

upstream raw materials:

N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)glyoxylamide

4,6-dimethoxy-3-phenylbenzofuran