isomimosifoliol

Base Information

• Chemical Name: isomimosifoliol
• CAS No.: 1396216-79-7
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.328
• Mol file: 1396216-79-7.mol

Synonyms:isomimosifoliol

Chemical Property of isomimosifoliol

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of isomimosifoliol

There total 5 articles about isomimosifoliol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H28NO3(1+)*I(1-) (1396216-71-9) → isomimosifoliol (1396216-79-7) + (±)-mimosifoliol

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 30 ℃; for 2.25h;

DOI:10.1080/00397911.2011.567882

Reference yield:

4-(3-dimethylamino-1-phenyl-propyl)2,5-dimethoxy-phenol (1342798-08-6) → isomimosifoliol (1396216-79-7) + (±)-mimosifoliol

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 20 °C

2: n-butyllithium / tetrahydrofuran; hexane / 2.25 h / 0 - 30 °C

With n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; 2: |Hofmann Elimination;

DOI:10.1080/00397911.2011.567882

Reference yield:

3-(dimethylamino)propiophenone hydrochloride (879-72-1) → isomimosifoliol (1396216-79-7) + (±)-mimosifoliol

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; sodium hydroxide / methanol; water / 3.5 h / 10 - 15 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 4 h / 135 - 140 °C

3.1: perchloric acid / dichloromethane / 3 h / 0 - 5 °C

4.1: dichloromethane / 1 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 2.25 h / 0 - 30 °C

With sodium tetrahydroborate; n-butyllithium; perchloric acid; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; 5.1: |Hofmann Elimination;

DOI:10.1080/00397911.2011.567882

upstream raw materials:

C₂₀H₂₈NO₃⁽¹⁺⁾*I^(1-)

N,N-dimethyl-3-hydroxy-3-phenylpropylamine

[3-(2,5-dimethoxy-phenoxy)-3-phenylpropyl]dimethylamine

4-(3-dimethylamino-1-phenyl-propyl)2,5-dimethoxy-phenol

Downstream raw materials:

dihydromimosifoliol