6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinamine

Base Information

Chemical Name:6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinamine
CAS No.:479612-84-5
Molecular Formula:C₁₂H₂₁ClN₂OSi
Molecular Weight:272.85
Hs Code.:

Synonyms:6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinamine

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Chemical Property of 6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinamine

Chemical Property:

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Technology Process of 6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinamine

There total 1 articles about 6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 479612-84-5
6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / water / 8 h / 165 °C / 14251.4 Torr / Sealed tube; Microwave irradiation

1.2: pH 3

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere

2.2: 0 - 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; ammonia; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 479612-84-5
6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinamine

: trans-4-[(4-(hydroxymethyl)-6-{[6-(1H-pyrazol-4-yl)-1,3-benzothiazol-2-yl]amino}-2-pyridinyl)amino]cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere; Cooling with ice; Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3: 2 h / 200 °C / Sealed tube; Microwave irradiation

4: caesium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 150 °C / Sealed tube; Microwave irradiation

With tetrabutyl ammonium fluoride; water; sodium hydride; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 479612-84-5
6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinamine

: 5-(2-{[6-[(trans-4-hydroxycyclohexyl)amino]-4-(4-morpholinylmethyl)-2-pyridinyl]amino}-1,3-benzothiazol-6-yl)-3-pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere; Cooling with ice; Reflux

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3.1: 2 h / 200 °C / Sealed tube; Microwave irradiation

4.1: manganese(IV) oxide / tetrahydrofuran / 6 h / 70 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 100 °C / Sealed tube; Microwave irradiation

6.1: acetic acid / dichloromethane / 0.17 h

6.2: 20 °C

With manganese(IV) oxide; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; mineral oil;