{6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indol-2-ylmethyl}-(2-morpholin-4-yl-ethyl)-amine

Base Information

Chemical Name:{6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indol-2-ylmethyl}-(2-morpholin-4-yl-ethyl)-amine
CAS No.:1067655-26-8
Molecular Formula:C₃₁H₃₁Cl₂N₅O
Molecular Weight:560.526
Hs Code.:

Synonyms:{6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indol-2-ylmethyl}-(2-morpholin-4-yl-ethyl)-amine

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Chemical Property of {6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indol-2-ylmethyl}-(2-morpholin-4-yl-ethyl)-amine

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Technology Process of {6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indol-2-ylmethyl}-(2-morpholin-4-yl-ethyl)-amine

There total 5 articles about {6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indol-2-ylmethyl}-(2-morpholin-4-yl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1067653-58-0
6-chloro-3-[3-(4-chlorobenzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indole-2-carboxylic acid (2-morpholin-4-ylethyl)amide

: 1067655-26-8
{6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indol-2-ylmethyl}-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: 6-chloro-3-[3-(4-chlorobenzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indole-2-carboxylic acid (2-morpholin-4-ylethyl)amide; With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; Heating / reflux;

With water; Rochelle's salt; In tetrahydrofuran;

Reference yield:

: 27034-51-1
ethyl 6-chloro-1H-indole-2-carboxylate

: 1067655-26-8
{6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indol-2-ylmethyl}-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 28 h / 50 °C

2.1: triethylamine / ethanol / 3 h / 60 °C

3.1: sodium hydroxide; ethanol; water / 2.5 h / Heating / reflux

3.2: 0 °C

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h / 50 °C

5.1: aluminum (III) chloride; lithium aluminium tetrahydride / tetrahydrofuran / Heating / reflux

With 4-methyl-morpholine; aluminum (III) chloride; sodium hydroxide; lithium aluminium tetrahydride; ethanol; water; triethylamine; HATU; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1067657-84-4
6-chloro-3-(1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl)-1H-indole-2-carboxylic acid

: 1067655-26-8
{6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indol-2-ylmethyl}-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h / 50 °C

2: aluminum (III) chloride; lithium aluminium tetrahydride / tetrahydrofuran / Heating / reflux

With 4-methyl-morpholine; aluminum (III) chloride; lithium aluminium tetrahydride; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;