1-[5-(tert-butyl)-2-(tetrahydro-2H-2-pyranyloxy)phenyl]-2-{4-iodo-2,5-di[3-(tetrahydro-2H-2-pyranyloxy)propoxy]phenyl}acetylene

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Chemical Name:1-[5-(tert-butyl)-2-(tetrahydro-2H-2-pyranyloxy)phenyl]-2-{4-iodo-2,5-di[3-(tetrahydro-2H-2-pyranyloxy)propoxy]phenyl}acetylene
CAS No.:195990-31-9
Molecular Formula:C₃₉H₅₃IO₈
Molecular Weight:776.75
Hs Code.:

Synonyms:1-[5-(tert-butyl)-2-(tetrahydro-2H-2-pyranyloxy)phenyl]-2-{4-iodo-2,5-di[3-(tetrahydro-2H-2-pyranyloxy)propoxy]phenyl}acetylene

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Chemical Property of 1-[5-(tert-butyl)-2-(tetrahydro-2H-2-pyranyloxy)phenyl]-2-{4-iodo-2,5-di[3-(tetrahydro-2H-2-pyranyloxy)propoxy]phenyl}acetylene

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Technology Process of 1-[5-(tert-butyl)-2-(tetrahydro-2H-2-pyranyloxy)phenyl]-2-{4-iodo-2,5-di[3-(tetrahydro-2H-2-pyranyloxy)propoxy]phenyl}acetylene

There total 3 articles about 1-[5-(tert-butyl)-2-(tetrahydro-2H-2-pyranyloxy)phenyl]-2-{4-iodo-2,5-di[3-(tetrahydro-2H-2-pyranyloxy)propoxy]phenyl}acetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 195990-30-8
2-[4-(tert-butyl)-2-(1-ethynyl)phenoxy]tetrahydro-2H-pyran

: 195990-29-5
1-{2,5-diiodo-4-[3-(tetrahydro-2H-2-pyranyloxy)propoxy]phenoxy}-3-(tetrahydro-2H-2-pyranyloxy)propane

: 195990-31-9
1-[5-(tert-butyl)-2-(tetrahydro-2H-2-pyranyloxy)phenyl]-2-{4-iodo-2,5-di[3-(tetrahydro-2H-2-pyranyloxy)propoxy]phenyl}acetylene

: C₅₆H₇₄O₁₀

Guidance literature:: With copper(l) iodide; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In triethylamine; at 70 ℃; for 11h;
DOI:10.1016/S0040-4020(97)00762-X

Reference yield:

: 13064-64-7
2,5-diiodo-1,4-hydroquinone

: 195990-31-9
1-[5-(tert-butyl)-2-(tetrahydro-2H-2-pyranyloxy)phenyl]-2-{4-iodo-2,5-di[3-(tetrahydro-2H-2-pyranyloxy)propoxy]phenyl}acetylene

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / potassium carbonate / dimethylformamide; H₂O / 20 °C

2: 100 percent / PPTS / 2 h / 50 °C

3: 65 percent / PPh₃; CuI / Pd(PPh₃)4 / triethylamine / 11 h / 70 °C

With copper(l) iodide; pyridinium p-toluenesulfonate; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; triethylamine; N,N-dimethyl-formamide; 1: Etherification / 2: Etherification / 3: Arylation;
DOI:10.1016/S0040-4020(97)00762-X

Reference yield:

: 195990-28-4
3,3'-((2,5-diiodo-1,4-phenylene)bis(oxy))bis(propan-1-ol)

: 195990-31-9
1-[5-(tert-butyl)-2-(tetrahydro-2H-2-pyranyloxy)phenyl]-2-{4-iodo-2,5-di[3-(tetrahydro-2H-2-pyranyloxy)propoxy]phenyl}acetylene

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / PPTS / 2 h / 50 °C

2: 65 percent / PPh₃; CuI / Pd(PPh₃)4 / triethylamine / 11 h / 70 °C

With copper(l) iodide; pyridinium p-toluenesulfonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In triethylamine; 1: Etherification / 2: Arylation;
DOI:10.1016/S0040-4020(97)00762-X