5-((2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl)-3-(2-methoxyethyl)-2-(3-thienyl)-4(3H)-pyrimidinone

Base Information

Chemical Name:5-((2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl)-3-(2-methoxyethyl)-2-(3-thienyl)-4(3H)-pyrimidinone
CAS No.:1269998-77-7
Molecular Formula:C₁₈H₁₈N₂O₅S
Molecular Weight:374.417
Hs Code.:

Synonyms:5-((2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl)-3-(2-methoxyethyl)-2-(3-thienyl)-4(3H)-pyrimidinone

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Chemical Property of 5-((2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl)-3-(2-methoxyethyl)-2-(3-thienyl)-4(3H)-pyrimidinone

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Technology Process of 5-((2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl)-3-(2-methoxyethyl)-2-(3-thienyl)-4(3H)-pyrimidinone

There total 4 articles about 5-((2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl)-3-(2-methoxyethyl)-2-(3-thienyl)-4(3H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1270000-80-0
1,6-dihydro-1-(2-methoxyethyl)-6-oxol-2-(3-thienyl)-5-pyrimidinecarboxylic acid

: 504-02-9
1,3-cylohexanedione

: 1269998-77-7
5-((2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl)-3-(2-methoxyethyl)-2-(3-thienyl)-4(3H)-pyrimidinone

Guidance literature:: 1,6-dihydro-1-(2-methoxyethyl)-6-oxol-2-(3-thienyl)-5-pyrimidinecarboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2h;

1,3-cylohexanedione; With triethylamine; 2-hydroxy-2-methylpropanenitrile; In dichloromethane; at 20 ℃; for 16.5h;

Reference yield:

: 1641-09-4
3-thiophenecarbonitrile

: 1269998-77-7
5-((2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl)-3-(2-methoxyethyl)-2-(3-thienyl)-4(3H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetyl chloride / dichloromethane / 0 - 20 °C

2.1: methanol / 1.5 h / 20 °C

2.2: 2 h / Reflux

3.1: lithium iodide / ethyl acetate / 16 h / Reflux

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

4.2: 0.5 h

4.3: 16 h / 20 °C

With oxalyl dichloride; acetyl chloride; lithium iodide; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 54610-58-1
ethyl thiophene-3-carbimidate hydrocloride

: 1269998-77-7
5-((2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl)-3-(2-methoxyethyl)-2-(3-thienyl)-4(3H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 1.5 h / 20 °C

1.2: 2 h / Reflux

2.1: lithium iodide / ethyl acetate / 16 h / Reflux

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3.2: 0.5 h

3.3: 16 h / 20 °C

With oxalyl dichloride; lithium iodide; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate;