2-tert-butyl-4-chloro-5-[4-(3-fluoropropoxy)benzyloxy]-3-(2H)-pyridazinone

Base Information

Chemical Name:2-tert-butyl-4-chloro-5-[4-(3-fluoropropoxy)benzyloxy]-3-(2H)-pyridazinone
CAS No.:863888-27-1
Molecular Formula:C₁₈H₂₂ClFN₂O₃
Molecular Weight:368.836
Hs Code.:

Synonyms:2-tert-butyl-4-chloro-5-[4-(3-fluoropropoxy)benzyloxy]-3-(2H)-pyridazinone

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Chemical Property of 2-tert-butyl-4-chloro-5-[4-(3-fluoropropoxy)benzyloxy]-3-(2H)-pyridazinone

Chemical Property:

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Technology Process of 2-tert-butyl-4-chloro-5-[4-(3-fluoropropoxy)benzyloxy]-3-(2H)-pyridazinone

There total 7 articles about 2-tert-butyl-4-chloro-5-[4-(3-fluoropropoxy)benzyloxy]-3-(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 863888-26-0
toluene-4-sulfonic acid 3-[4-(1-tert-5 butyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)phenoxy]propyl ester

: 863888-27-1
2-tert-butyl-4-chloro-5-[4-(3-fluoropropoxy)benzyloxy]-3-(2H)-pyridazinone

Guidance literature:: With potassium fluoride; [2.2.2]cryptande; In acetonitrile; for 0.666667h;
DOI:10.1021/jm701443n

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 863888-27-1
2-tert-butyl-4-chloro-5-[4-(3-fluoropropoxy)benzyloxy]-3-(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 2 h

3: lithium aluminium tetrahydride / diethyl ether / 2 h / Cooling with ice

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / Cooling with ice

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

6: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

7: potassium fluoride; [2.2.2]cryptande / acetonitrile / 0.67 h / 90 °C

With 1H-imidazole; dmap; potassium fluoride; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; [2.2.2]cryptande; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3981-65-5
4-(3-hydroxypropoxy)-benzoic acid methyl ester

: 863888-27-1
2-tert-butyl-4-chloro-5-[4-(3-fluoropropoxy)benzyloxy]-3-(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 2 h

2: lithium aluminium tetrahydride / diethyl ether / 2 h / Cooling with ice

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / Cooling with ice

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

5: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

6: potassium fluoride; [2.2.2]cryptande / acetonitrile / 0.67 h / 90 °C

With 1H-imidazole; dmap; potassium fluoride; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; [2.2.2]cryptande; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;