(E)-methyl 3-(2-fluorophenyl)-2-((3-methyl-1H-indol-1-yl)methyl)acrylate

Base Information

Chemical Name:(E)-methyl 3-(2-fluorophenyl)-2-((3-methyl-1H-indol-1-yl)methyl)acrylate
CAS No.:1609258-03-8
Molecular Formula:C₂₀H₁₈FNO₂
Molecular Weight:323.367
Hs Code.:

Synonyms:(E)-methyl 3-(2-fluorophenyl)-2-((3-methyl-1H-indol-1-yl)methyl)acrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-methyl 3-(2-fluorophenyl)-2-((3-methyl-1H-indol-1-yl)methyl)acrylate

Chemical Property:

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Technology Process of (E)-methyl 3-(2-fluorophenyl)-2-((3-methyl-1H-indol-1-yl)methyl)acrylate

There total 1 articles about (E)-methyl 3-(2-fluorophenyl)-2-((3-methyl-1H-indol-1-yl)methyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 83-34-1
3-Methylindole

: (Z)-methyl 2-(bromomethyl)-3-(fluorophenyl)acrylate

: 1609258-03-8
(E)-methyl 3-(2-fluorophenyl)-2-((3-methyl-1H-indol-1-yl)methyl)acrylate

Guidance literature:: With tetrabutylammomium bromide; sodium hydroxide; In toluene; at 20 ℃; for 4h;
DOI:10.1016/j.tetlet.2014.03.134

Reference yield: 90.0%

: 1609258-03-8
(E)-methyl 3-(2-fluorophenyl)-2-((3-methyl-1H-indol-1-yl)methyl)acrylate

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1609257-75-1
(E)-methyl 3-(2-fluorophenyl)-2-((2-formyl-3-methyl-1H-indol-1-yl)methyl)acrylate

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 10 - 20 ℃; for 0.333333h; Inert atmosphere;

(E)-methyl 3-(2-fluorophenyl)-2-((3-methyl-1H-indol-1-yl)methyl)acrylate; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.03.134

Reference yield:

: 1609258-03-8
(E)-methyl 3-(2-fluorophenyl)-2-((3-methyl-1H-indol-1-yl)methyl)acrylate

: methyl 3-(2-fluorophenyl)-10-methyl-2-phenyl-2,3,3a,4-tetrahydropyrazolo[3',4':3,4]pyrrolo[1,2-a]indole-3a-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0.33 h / 10 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: hydrogenchloride / ethanol; water / 1 h / 0 - 80 °C / Microwave irradiation

With hydrogenchloride; trichlorophosphate; In ethanol; water; 1.1: |Vilsmeier-Haack Formylation / 1.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.tetlet.2014.03.134