Technology Process of Cyclobutanemethanol, 2,2-dimethyl-3-(1-methylethylidene)-, (1S)- (9CI)
There total 8 articles about Cyclobutanemethanol, 2,2-dimethyl-3-(1-methylethylidene)-, (1S)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 20 ℃;
DOI:10.1021/jf048198k
- Guidance literature:
-
(R)-(-)-2,2-dimethyl-3-(1-methylethylidene)cyclobutanecarboxylic acid;
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 20 ℃;
Inert atmosphere;
Cooling with ice;
With
water; sodium hydroxide;
for 0.5h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: MeLi / tetrahydrofuran; diethyl ether / 0.25 h / -20 °C
1.2: tetrahydrofuran; diethyl ether / 1.5 h / -10 - 20 °C
2.1: POCl3; pyridine / 24 h / 20 °C
3.1: p-toluenesulfonic acid / benzene / 24 h / Heating
4.1: 88 percent / LiAlH4 / diethyl ether / 20 °C
With
pyridine; lithium aluminium tetrahydride; methyllithium; toluene-4-sulfonic acid; trichlorophosphate;
In
tetrahydrofuran; diethyl ether; benzene;
DOI:10.1021/jf048198k
