(R)-5-bromo-1-(3,5-dichlorophenyl)-3-methyl-3-(4-(trifluoromethoxy)benzyl)-1H-[8-⁽¹⁴⁾C]imidazo[1,2-a]imidazol-2(3H)-one

Base Information

• Chemical Name: (R)-5-bromo-1-(3,5-dichlorophenyl)-3-methyl-3-(4-(trifluoromethoxy)benzyl)-1H-[8-⁽¹⁴⁾C]imidazo[1,2-a]imidazol-2(3H)-one
• CAS No.: 1356585-18-6
• Molecular Formula: C₂₀H₁₃BrCl₂F₃N₃O₂
• Molecular Weight: 537.136

Synonyms:(R)-5-bromo-1-(3,5-dichlorophenyl)-3-methyl-3-(4-(trifluoromethoxy)benzyl)-1H-[8-⁽¹⁴⁾C]imidazo[1,2-a]imidazol-2(3H)-one

Chemical Property of (R)-5-bromo-1-(3,5-dichlorophenyl)-3-methyl-3-(4-(trifluoromethoxy)benzyl)-1H-[8-⁽¹⁴⁾C]imidazo[1,2-a]imidazol-2(3H)-one

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Technology Process of (R)-5-bromo-1-(3,5-dichlorophenyl)-3-methyl-3-(4-(trifluoromethoxy)benzyl)-1H-[8-⁽¹⁴⁾C]imidazo[1,2-a]imidazol-2(3H)-one

There total 1 articles about (R)-5-bromo-1-(3,5-dichlorophenyl)-3-methyl-3-(4-(trifluoromethoxy)benzyl)-1H-[8-⁽¹⁴⁾C]imidazo[1,2-a]imidazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(5R)-7-(3,5-dichlorophenyl)-5-methyl-5-[[4-(trifluoromethoxy)phenyl]methyl][8-(14)C]imidazo[1,2-a]imidazol-6-one (1356585-16-4) → (R)-5-bromo-1-(3,5-dichlorophenyl)-3-methyl-3-(4-(trifluoromethoxy)benzyl)-1H-[8-(14)C]imidazo[1,2-a]imidazol-2(3H)-one (1356585-18-6)

Guidance literature:

With N-Bromosuccinimide; triethylamine; In dichloromethane; at 0 - 20 ℃; for 14.5h;

DOI:10.1002/jlcr.1934

Reference yield:

(R)-5-bromo-1-(3,5-dichlorophenyl)-3-methyl-3-(4-(trifluoromethoxy)benzyl)-1H-[8-(14)C]imidazo[1,2-a]imidazol-2(3H)-one (1356585-18-6) → (5R)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-5-[[4-(trifluoromethoxy)phenyl]methyl][8-(14)C]imidazo[1,2-a]imidazole-3-sulfonyl chloride (1356585-19-7)

Guidance literature:

(R)-5-bromo-1-(3,5-dichlorophenyl)-3-methyl-3-(4-(trifluoromethoxy)benzyl)-1H-[8-⁽¹⁴⁾C]imidazo[1,2-a]imidazol-2(3H)-one; With isopropylmagnesium chloride; In tetrahydrofuran; at -10 ℃;

With sulfur dioxide; In tetrahydrofuran; for 0.25h;

With N-chloro-succinimide; In tetrahydrofuran; for 0.25h;

DOI:10.1002/jlcr.1934

Reference yield:

(R)-5-bromo-1-(3,5-dichlorophenyl)-3-methyl-3-(4-(trifluoromethoxy)benzyl)-1H-[8-(14)C]imidazo[1,2-a]imidazol-2(3H)-one (1356585-18-6) → (2S)-2-[[(5R)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-5-[[4-(trifluoromethoxy)phenyl]methyl][8-(14)C]imidazo[1,2-a]imidazol-3-yl]sulfonylamino]propanamide (1356585-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / -10 °C

1.2: 0.25 h

1.3: 0.25 h

2.1: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With isopropylmagnesium chloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.1934

upstream raw materials:

(5R)-7-(3,5-dichlorophenyl)-5-methyl-5-[[4-(trifluoromethoxy)phenyl]methyl][8-⁽¹⁴⁾C]imidazo[1,2-a]imidazol-6-one

Downstream raw materials:

(R)-1-(3,5-dichlorophenyl)-3-methyl-2-oxo-3-(4-(trifluoromethoxy)benzyl)-2,3-dihydro-1H-[8-⁽¹⁴⁾C]imidazo[1,2-a]imidazole-5-sulfonamide

(5R)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-5-[[4-(trifluoromethoxy)phenyl]methyl][8-⁽¹⁴⁾C]imidazo[1,2-a]imidazole-3-sulfonyl chloride

(2S)-2-[[(5R)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-5-[[4-(trifluoromethoxy)phenyl]methyl][8-⁽¹⁴⁾C]imidazo[1,2-a]imidazol-3-yl]sulfonylamino]propanamide

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