ethyl diethoxymethyl-(S_S,R_C,R_P)-(+)-(1-(tert-butylsulfonylamino)-(1-(p-nitrophenyl)ethyl))phosphinate

Base Information

• Chemical Name: ethyl diethoxymethyl-(S_S,R_C,R_P)-(+)-(1-(tert-butylsulfonylamino)-(1-(p-nitrophenyl)ethyl))phosphinate
• CAS No.: 1058227-63-6
• Molecular Formula: C₁₉H₃₃N₂O₈PS
• Molecular Weight: 480.519

Synonyms:ethyl diethoxymethyl-(S_S,R_C,R_P)-(+)-(1-(tert-butylsulfonylamino)-(1-(p-nitrophenyl)ethyl))phosphinate

Chemical Property of ethyl diethoxymethyl-(S_S,R_C,R_P)-(+)-(1-(tert-butylsulfonylamino)-(1-(p-nitrophenyl)ethyl))phosphinate

Chemical Property:

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Technology Process of ethyl diethoxymethyl-(S_S,R_C,R_P)-(+)-(1-(tert-butylsulfonylamino)-(1-(p-nitrophenyl)ethyl))phosphinate

There total 1 articles about ethyl diethoxymethyl-(S_S,R_C,R_P)-(+)-(1-(tert-butylsulfonylamino)-(1-(p-nitrophenyl)ethyl))phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl diethoxymethyl-(SS,RC,RP)-(+)-(1-(tert-butylsulfinylamino)-(1-(p-nitrophenyl)ethyl))phosphinate (1058227-33-0) → ethyl diethoxymethyl-(SS,RC,RP)-(+)-(1-(tert-butylsulfonylamino)-(1-(p-nitrophenyl)ethyl))phosphinate (1058227-63-6)

Guidance literature:

With ruthenium trichloride; sodium periodate; In dichloromethane; water; acetonitrile; at 20 ℃; optical yield given as %ee;

DOI:10.1002/chem.200800690

Reference yield:

ethyl diethoxymethyl-(SS,RC,RP)-(+)-(1-(tert-butylsulfonylamino)-(1-(p-nitrophenyl)ethyl))phosphinate (1058227-63-6) → ethyl methyl (R)-((R)-1-(1,1-dimethylethylsulfonamido)-1-(4-nitrophenyl)ethyl)phosphonate (1410782-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / chloroform

2: bromine; triethylamine / acetonitrile / 20 °C

With boron trifluoride diethyl etherate; bromine; triethylamine; In chloroform; acetonitrile;

DOI:10.1021/jo302140q

Reference yield:

ethyl diethoxymethyl-(SS,RC,RP)-(+)-(1-(tert-butylsulfonylamino)-(1-(p-nitrophenyl)ethyl))phosphinate (1058227-63-6) → ethyl (R)-((R)-1-(4-nitrophenyl)-1-(1,1-dimethylethylsulfonamido)ethyl)phosphinate (1410782-33-0)

Guidance literature:

With boron trifluoride diethyl etherate; In chloroform;

DOI:10.1021/jo302140q

upstream raw materials:

ethyl diethoxymethyl-(S_S,R_C,R_P)-(+)-(1-(tert-butylsulfinylamino)-(1-(p-nitrophenyl)ethyl))phosphinate

Downstream raw materials:

ethyl methyl (R)-((R)-1-(1,1-dimethylethylsulfonamido)-1-(4-nitrophenyl)ethyl)phosphonate

ethyl (R)-((R)-1-(4-nitrophenyl)-1-(1,1-dimethylethylsulfonamido)ethyl)phosphinate

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