1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}-4-(pyridin-2-ylcarbamoyl)piperidine-4-carboxylic acid benzyl ester

Base Information

Chemical Name:1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}-4-(pyridin-2-ylcarbamoyl)piperidine-4-carboxylic acid benzyl ester
CAS No.:1093213-64-9
Molecular Formula:C₄₀H₃₄FN₅O₄
Molecular Weight:667.739
Hs Code.:

Synonyms:1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}-4-(pyridin-2-ylcarbamoyl)piperidine-4-carboxylic acid benzyl ester

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Chemical Property of 1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}-4-(pyridin-2-ylcarbamoyl)piperidine-4-carboxylic acid benzyl ester

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Technology Process of 1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}-4-(pyridin-2-ylcarbamoyl)piperidine-4-carboxylic acid benzyl ester

There total 10 articles about 1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}-4-(pyridin-2-ylcarbamoyl)piperidine-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 504-29-0
2-aminopyridine

: 1093214-95-9
4-chlorocarbonyl-1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid benzyl ester

: 1093213-64-9
1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}-4-(pyridin-2-ylcarbamoyl)piperidine-4-carboxylic acid benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 50 ℃; for 1h;

Reference yield:

: 41604-19-7
1-bromo-3-fluoro-4-phenylbenzene

: 1093213-64-9
1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}-4-(pyridin-2-ylcarbamoyl)piperidine-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: iodine; magnesium / tetrahydrofuran / 1 h / 60 - 70 °C / Heating / reflux

1.2: 0.75 h / -20 °C

2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 2.33 h / 5 - 20 °C

2.2: 2 h / 20 - 25 °C

3.1: toluene-4-sulfonic acid / N,N-dimethyl acetamide; toluene / 2 - 3 h / 105 - 115 °C

4.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 80 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2.5 h / 90 °C

6.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 80 °C

6.2: 20 °C / pH 9

7.1: potassium carbonate / tetrabutylammomium bromide / N,N-dimethyl-formamide / 4 h / 100 °C

8.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

8.2: pH ~ 6

9.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / 0 - 50 °C

10.1: triethylamine / dichloromethane / 1 h / 0 - 50 °C

With sodium hydroxide; thionyl chloride; oxalyl dichloride; water; iodine; potassium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; tetrabutylammomium bromide; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 137045-30-8
2-fluoro-4-biphenylacetic acid

: 1093213-64-9
1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}-4-(pyridin-2-ylcarbamoyl)piperidine-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 2 - 3 h / 130 - 140 °C

2.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 80 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2.5 h / 90 °C

4.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 80 °C

4.2: 20 °C / pH 9

5.1: potassium carbonate / tetrabutylammomium bromide / N,N-dimethyl-formamide / 4 h / 100 °C

6.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

6.2: pH ~ 6

7.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / 0 - 50 °C

8.1: triethylamine / dichloromethane / 1 h / 0 - 50 °C

With sodium hydroxide; thionyl chloride; oxalyl dichloride; water; potassium carbonate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; tetrabutylammomium bromide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;