1-(4-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenyl)piperidine

Base Information

• Chemical Name: 1-(4-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenyl)piperidine
• CAS No.: 1376656-14-2
• Molecular Formula: C₂₄H₂₈N₆
• Molecular Weight: 400.527

Synonyms:1-(4-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenyl)piperidine

Chemical Property of 1-(4-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenyl)piperidine

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Technology Process of 1-(4-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenyl)piperidine

There total 2 articles about 1-(4-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(E)-1-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-3-(4-(piperidin-1-yl)phenyl)prop-2-en-1-one (1376656-06-2) → 1-(4-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenyl)piperidine (1376656-14-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

DOI:10.1016/j.ejmech.2012.03.023

Reference yield:

4-(piperidin-1-yl)benzaldehyde (10338-57-5) → 1-(4-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenyl)piperidine (1376656-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 4 h / 20 - 25 °C

2: hydrazine hydrate / ethanol / 6 h / Reflux

With hydrazine hydrate; sodium hydroxide; In ethanol; water;

DOI:10.1016/j.ejmech.2012.03.023

Reference yield: 69.0%

1-(4-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenyl)piperidine (1376656-14-2) + Benzoyl isothiocyanate (532-55-8) → N-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-5-(4-(piperidin-1-yl)phenyl)-4,5-dihydro-1H-pyrazole-1-carbonothioyl)benzamide (1376656-22-2)

Guidance literature:

In ethanol; for 5h; Reflux;

DOI:10.1016/j.ejmech.2012.03.023

upstream raw materials:

4-(piperidin-1-yl)benzaldehyde

(E)-1-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-3-(4-(piperidin-1-yl)phenyl)prop-2-en-1-one

Downstream raw materials:

N-(3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-5-(4-(piperidin-1-yl)phenyl)-4,5-dihydro-1H-pyrazole-1-carbonothioyl)benzamide

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