{2-[5-(3-fluoro-2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{2-[5-(3-fluoro-2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid tert-butyl ester
CAS No.:228259-38-9
Molecular Formula:C₃₃H₃₅F₄N₅O₅S
Molecular Weight:689.731
Hs Code.:

Synonyms:{2-[5-(3-fluoro-2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {2-[5-(3-fluoro-2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of {2-[5-(3-fluoro-2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid tert-butyl ester

There total 12 articles about {2-[5-(3-fluoro-2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 209919-51-7
(2'-tert-butylaminosulfonyl-3-fluoro-[1,1']-biphen-4-yl)amine

: [2-(5-chlorocarbonyl-3-trifluoromethyl-pyrazol-1-yl)-benzyl]-carbamic acid tert-butyl ester

: 228259-38-9
{2-[5-(3-fluoro-2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid tert-butyl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;
DOI:10.1021/jm030212h

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 228259-38-9
{2-[5-(3-fluoro-2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 4.76 g / aq. NH₃ / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 100 percent / Et₃N; trichloroacetyl chloride / CH₂Cl₂ / 1.42 h / 0 - 20 °C

5: 90 percent / cobalt chloride; sodium borohydride / dimethylformamide / 23.75 h / 0 - 20 °C

6: 76 percent / Et₃N / tetrahydrofuran / 17 h / 20 °C

7: 27 percent / KMnO₄; aq. NaH₂PO₄ / 2-methyl-propan-2-ol / 1.25 h / 60 °C

8: oxalyl chloride; DMF / CH₂Cl₂ / 1.58 h / 20 °C

9: DMAP / CH₂Cl₂ / 20 °C

With dmap; ammonium hydroxide; sodium tetrahydroborate; potassium permanganate; sodium dihydrogenphosphate; cobalt chloride; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetyl chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm030212h

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 228259-38-9
{2-[5-(3-fluoro-2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; H₂O / 18 h / Heating

2: DMAP / CH₂Cl₂ / 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm030212h