C₁₈H₂₆O₅

Base Information

• Chemical Name: C₁₈H₂₆O₅
• CAS No.: 947613-22-1
• Molecular Formula: C₁₈H₂₆O₅
• Molecular Weight: 322.401
• Mol file: 947613-22-1.mol

Synonyms:C₁₈H₂₆O₅

Chemical Property of C₁₈H₂₆O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₆O₅

There total 8 articles about C₁₈H₂₆O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(4R,5S,6S)-2-(4-methoxyphenyl)-5-methyl-[1,3]dioxin-4-yl]propionaldehyde (398518-78-0) + 2-(Trimethylsilyloxy)propene (1833-53-0) → C18H26O5 (947613-22-1)

Guidance literature:

With borontrifluoride-ethyletherate; In toluene; at -78 ℃; for 0.00277778h;

DOI:10.1002/anie.200605198

Reference yield:

C25H29NO6 (947613-25-4) → C18H26O5 (947613-22-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: LiBH₄ / ethanol; tetrahydrofuran / 4 h / 20 °C

2.1: oxalyl chloride; DMSO / CH₂Cl₂ / 1 h / -45 °C

2.2: 99 percent / NEt₃ / CH₂Cl₂ / 0.25 h / 0 °C

3.1: borontrifluoride-ethyletherate / toluene / 0 h / -78 °C

With lithium borohydride; oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane; toluene; 3.1: anti-Felkin-selective Mukaiyama aldol reaction;

DOI:10.1002/anie.200605198

Reference yield:

O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) → C18H26O5 (947613-22-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 91 percent / camphersulfonic acid / CH₂Cl₂ / 16 h / 20 °C

2.1: 76 percent / diisobutylaluminum hydride / toluene; CH₂Cl₂ / 0.5 h / -78 °C

3.1: oxalyl chloride; DMSO / CH₂Cl₂ / 1 h / -45 °C

3.2: 95 percent / NEt₃ / CH₂Cl₂ / 0.25 h / 0 °C

4.1: Bu₂BOTf; NEt₃ / CH₂Cl₂ / 0.75 h / 0 °C

4.2: 85 percent / CH₂Cl₂ / 1 h / 0 °C

5.1: 73 percent / 2,3-dichloro-5,6-dicyan-1,4-benzoquinone; 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h / 0 °C

6.1: LiBH₄ / ethanol; tetrahydrofuran / 4 h / 20 °C

7.1: oxalyl chloride; DMSO / CH₂Cl₂ / 1 h / -45 °C

7.2: 99 percent / NEt₃ / CH₂Cl₂ / 0.25 h / 0 °C

8.1: borontrifluoride-ethyletherate / toluene / 0 h / -78 °C

With lithium borohydride; oxalyl dichloride; 4 A molecular sieve; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; ethanol; dichloromethane; toluene; 4.2: Evans aldol reaction / 8.1: anti-Felkin-selective Mukaiyama aldol reaction;

DOI:10.1002/anie.200605198

upstream raw materials:

2-[(4R,5S,6S)-2-(4-methoxyphenyl)-5-methyl-[1,3]dioxin-4-yl]propionaldehyde

2-(Trimethylsilyloxy)propene

C₂₅H₂₉NO₆

O-(4-methoxybenzyl)-trichloroacetimidate

Downstream raw materials:

C₁₈H₂₈O₅

C₃₀H₅₆O₅Si₂