8-[3-aza(N-tosyl)hex-5-en-1-yl]-2,2-dimethyl-1,3-benzodioxin

Base Information

• Chemical Name: 8-[3-aza(N-tosyl)hex-5-en-1-yl]-2,2-dimethyl-1,3-benzodioxin
• CAS No.: 1351998-29-2
• Molecular Formula: C₂₂H₂₇NO₄S
• Molecular Weight: 401.527
• Mol file: 1351998-29-2.mol

Synonyms:8-[3-aza(N-tosyl)hex-5-en-1-yl]-2,2-dimethyl-1,3-benzodioxin

Chemical Property of 8-[3-aza(N-tosyl)hex-5-en-1-yl]-2,2-dimethyl-1,3-benzodioxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-[3-aza(N-tosyl)hex-5-en-1-yl]-2,2-dimethyl-1,3-benzodioxin

There total 2 articles about 8-[3-aza(N-tosyl)hex-5-en-1-yl]-2,2-dimethyl-1,3-benzodioxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

4-methyl-N-(2-propenyl)benzenesulfonamide (50487-71-3) + 8-(2-bromoethyl)-2,2-dimethyl-1,3-benzodioxin (1351998-27-0) → 8-vinyl-2,2-dimethyl-1,3-benzodioxin (1351998-28-1) + 8-[3-aza(N-tosyl)hex-5-en-1-yl]-2,2-dimethyl-1,3-benzodioxin (1351998-29-2)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In acetonitrile; for 24h; Reflux;

DOI:10.1016/j.tet.2011.10.061

Reference yield:

C12H16O3 (1234791-13-9) → 8-vinyl-2,2-dimethyl-1,3-benzodioxin (1351998-28-1) + 8-[3-aza(N-tosyl)hex-5-en-1-yl]-2,2-dimethyl-1,3-benzodioxin (1351998-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole; bromine; triphenylphosphine / dichloromethane / 3.17 h / 0 - 20 °C

2: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / acetonitrile / 24 h / Reflux

With 1H-imidazole; N-benzyl-N,N,N-triethylammonium chloride; bromine; potassium carbonate; triphenylphosphine; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2011.10.061

Reference yield: 94.0%

8-[3-aza(N-tosyl)hex-5-en-1-yl]-2,2-dimethyl-1,3-benzodioxin (1351998-29-2) → 2-[3-aza(N-tosyl)hex-5-en-1-yl]-6-hydroxymethylphenol (1351998-24-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 12h;

DOI:10.1016/j.tet.2011.10.061

upstream raw materials:

C₁₂H₁₆O₃

4-methyl-N-(2-propenyl)benzenesulfonamide

8-(2-bromoethyl)-2,2-dimethyl-1,3-benzodioxin

Downstream raw materials:

C₁₉H₂₁NO₄S

C₃₈H₄₂N₂O₈S₂

2-[3-aza(N-tosyl)hex-5-en-1-yl]-6-hydroxymethylphenol