2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide

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Chemical Name:2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide
CAS No.:1334675-71-6
Molecular Formula:C₃₂H₃₈N₈O₃Si
Molecular Weight:610.791
Hs Code.:

2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide

Synonyms:2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide

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Chemical Property of 2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide

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Technology Process of 2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide

There total 12 articles about 2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1334675-70-5
2-methyl-1-phenyl-4-tributylstannanyl-1H-imidazole

: 1334675-67-0
2-bromo-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide

: 1334675-71-6
2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; for 18h; Inert atmosphere; Heating;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1334675-71-6
2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran

2.2: pH 4

3.1: Jones reagent / water; acetone / 0.25 h

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

4.2: 0 - 20 °C

5.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 2.25 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Cooling with ice

6.2: 18 h

7.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; N,N-dimethyl-formamide / 18 h / Inert atmosphere; Heating

With sodium chlorite; potassium dihydrogenphosphate; copper(l) iodide; Jones reagent; aminosulfonic acid; water; sodium hydride; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1334675-71-6
2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 0 - 20 °C

2.1: chloroform / 8 h / 20 °C / Reflux; Inert atmosphere

3.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 2.25 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Cooling with ice

4.2: 18 h

5.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; N,N-dimethyl-formamide / 18 h / Inert atmosphere; Heating

With sodium chlorite; potassium dihydrogenphosphate; copper(l) iodide; aminosulfonic acid; sodium hydride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;