dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate

Base Information

• Chemical Name: dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate
• CAS No.: 1337952-20-1
• Molecular Formula: C₁₅H₁₈O₆
• Molecular Weight: 294.304
• Mol file: 1337952-20-1.mol

Synonyms:dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate

Chemical Property of dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate

There total 1 articles about dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

trimethylsulfoxonium iodide (1774-47-6) + dimethyl 2-(2,3-dimethoxybenzylidene)malonate (122480-76-6) → dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate (1337952-20-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/ol5007218 DOI:10.1021/ol501763n

Reference yield: 90.0%

1,2,3-trimethoxybenzene (621-23-8) + dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate (1337952-20-1) → dimethyl 2-[2-(2,3-dimethoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethyl]malonate

Guidance literature:

With ytterbium(III) triflate; In 1,2-dichloro-ethane; at 20 - 65 ℃; Catalytic behavior; Inert atmosphere;

DOI:10.1016/j.tet.2015.12.001

Reference yield: 90.0%

dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate (1337952-20-1) + malononitrile (109-77-3) → dimethyl 2-amino-3-cyano-4-(2,3-dimethoxyphenyl)cyclopent-2-ene-1,1-dicarboxylate (1451073-77-0)

Guidance literature:

malononitrile; With sodium hydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate; With ytterbium(III) triflate; In tetrahydrofuran; at 60 ℃; for 0.25h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; Inert atmosphere;

DOI:10.1039/c3cc44533j

upstream raw materials:

trimethylsulfoxonium iodide

dimethyl 2-(2,3-dimethoxybenzylidene)malonate

Downstream raw materials:

dimethyl 2-amino-3-cyano-4-(2,3-dimethoxyphenyl)cyclopent-2-ene-1,1-dicarboxylate