5-(3(S)-hydroxy-4-{[(p-tolylmethyl)sulfonyl]oxy}butyl)thiophene-2-carboxylic acid ethyl ester

Base Information

Chemical Name:5-(3(S)-hydroxy-4-{[(p-tolylmethyl)sulfonyl]oxy}butyl)thiophene-2-carboxylic acid ethyl ester
CAS No.:186521-23-3
Molecular Formula:C₁₈H₂₂O₆S₂
Molecular Weight:398.501
Hs Code.:

Synonyms:5-(3(S)-hydroxy-4-{[(p-tolylmethyl)sulfonyl]oxy}butyl)thiophene-2-carboxylic acid ethyl ester

Suppliers and Price of 5-(3(S)-hydroxy-4-{[(p-tolylmethyl)sulfonyl]oxy}butyl)thiophene-2-carboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5-(3(S)-hydroxy-4-{[(p-tolylmethyl)sulfonyl]oxy}butyl)thiophene-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-(3(S)-hydroxy-4-{[(p-tolylmethyl)sulfonyl]oxy}butyl)thiophene-2-carboxylic acid ethyl ester

There total 4 articles about 5-(3(S)-hydroxy-4-{[(p-tolylmethyl)sulfonyl]oxy}butyl)thiophene-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 98-59-9
p-toluenesulfonyl chloride

: 186521-22-2,208337-83-1
5-(3(S)-4-dihydroxy-butyl)-thiophene-2-carboxylic acid ethyl ester

: 186521-23-3
5-(3(S)-hydroxy-4-{[(p-tolylmethyl)sulfonyl]oxy}butyl)thiophene-2-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/jm9607459

Reference yield:

: 5751-83-7
ethyl 5-bromothiophene-2-carboxylate

: 186521-23-3
5-(3(S)-hydroxy-4-{[(p-tolylmethyl)sulfonyl]oxy}butyl)thiophene-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CuI, (Ph₃P)2PdCl₂ / diethylamine / Ambient temperature

2: H₂ / 5percent Pd-C / ethanol / 3.5 h / 2327.2 Torr

3: 98 percent / p-toluenesulfonic acid monohydrate, EtOH / 3 h / 65 °C

4: 66 percent / Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethanol; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; diethylamine;
DOI:10.1021/jm9607459

Reference yield:

: 186521-20-0
5-(2,2-dimethyl-[1,3]dioxolan-4(S)-yl-ethynyl)-thiophene-2-carboxylic acid ethyl ester

: 186521-23-3
5-(3(S)-hydroxy-4-{[(p-tolylmethyl)sulfonyl]oxy}butyl)thiophene-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 5percent Pd-C / ethanol / 3.5 h / 2327.2 Torr

2: 98 percent / p-toluenesulfonic acid monohydrate, EtOH / 3 h / 65 °C

3: 66 percent / Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

With ethanol; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm9607459