1-((3,7-dimethyloctyl)oxy)-4-ethynylbenzene

Base Information

• Chemical Name: 1-((3,7-dimethyloctyl)oxy)-4-ethynylbenzene
• CAS No.: 1013637-04-1
• Molecular Formula: C₁₈H₂₆O
• Molecular Weight: 258.404
• Mol file: 1013637-04-1.mol

Synonyms:1-((3,7-dimethyloctyl)oxy)-4-ethynylbenzene

Chemical Property of 1-((3,7-dimethyloctyl)oxy)-4-ethynylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((3,7-dimethyloctyl)oxy)-4-ethynylbenzene

There total 8 articles about 1-((3,7-dimethyloctyl)oxy)-4-ethynylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

((4-((3,7-dimethyloctyl)oxy)phenyl)ethynyl)trimethylsilane (1337927-36-2) → 1-((3,7-dimethyloctyl)oxy)-4-ethynylbenzene (1013637-04-1)

Guidance literature:

With water; potassium carbonate; In tetrahydrofuran; methanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol3017353

Reference yield:

1-bromo-4-((3,7-dimethyloctyl)oxy)benzene (209673-74-5) → 1-((3,7-dimethyloctyl)oxy)-4-ethynylbenzene (1013637-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CuI; Et₃N / Pd(II)

2: KOH / toluene / Heating

With potassium hydroxide; copper(l) iodide; triethylamine; palladium (II) ion; In toluene;

DOI:10.1080/15421400390213573

Reference yield:

1-bromo-3,7-dimethyloctane (59965-20-7,72746-96-4,79434-89-2,3383-83-3) → 1-((3,7-dimethyloctyl)oxy)-4-ethynylbenzene (1013637-04-1)

Guidance literature:

Multi-step reaction with 3 steps

1: CuI; Et₃N / Pd(II)

2: KOH / toluene / Heating

With potassium hydroxide; copper(l) iodide; triethylamine; palladium (II) ion; In toluene;

DOI:10.1080/15421400390213573

upstream raw materials:

4-bromo-phenol

1-bromo-3,7-dimethyloctane

1-bromo-4-((3,7-dimethyloctyl)oxy)benzene

((4-((3,7-dimethyloctyl)oxy)phenyl)ethynyl)trimethylsilane

Downstream raw materials:

C₃₈H₃₉BrO₃S

C₃₈H₃₉BrO₃S

4,8-bis(4-(3,7-dimethyloctyloxy)phenylethynyl)-2,6-dimethylbenzo[1,2-d-4,5-d']bisoxazole

C₅₀H₄₁BrO

Refernces

• 1、 Xu, Feng,Peng, Lifen,Wakamatsu, Kan,Orita, Akihiro,Otera, Junzo. "Nucleophilic substitution in 16π-antiaromatic system: Synthesis of heteroatom-substituted dibenzopentalenes". . p. 1548 - 1550. Retrieved 2014.
• 2、 Ghizzoni, Massimo,Wu, Jiang,Gao, Tielong,Haisma, Hidde J.,Dekker, Frank J.,George Zheng. "6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site". . p. 337 - 344. Retrieved 2012/03/09.