[4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-phenyl-acetic acid

Base Information

• Chemical Name: [4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-phenyl-acetic acid
• CAS No.: 480994-31-8
• Molecular Formula: C₂₆H₂₇N₃O₅
• Molecular Weight: 461.517

Synonyms:[4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-phenyl-acetic acid

Chemical Property of [4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-phenyl-acetic acid

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Technology Process of [4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-phenyl-acetic acid

There total 3 articles about [4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-phenyl-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

{4-[(E)-2-(5-Nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-phenyl-acetic acid (875802-11-2) → [4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-phenyl-acetic acid (480994-31-8)

Guidance literature:

With formic acid; sodium dithionite; Heating;

DOI:10.1021/jm0506221

Reference yield:

2-(4-FORMYLPHENOXY)-2-PHENYLACETIC ACID (480994-56-7) → [4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-phenyl-acetic acid (480994-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / dioxane / Heating

2: 90 percent / formic acid; sodium dithionite / Heating

With piperidine; formic acid; sodium dithionite; In 1,4-dioxane;

DOI:10.1021/jm0506221

Reference yield:

6-methyl-5-nitro-1,3-dipropyl-1H-pyrimidine-2,4-dione (157119-79-4) → [4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-phenyl-acetic acid (480994-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / dioxane / Heating

2: 90 percent / formic acid; sodium dithionite / Heating

With piperidine; formic acid; sodium dithionite; In 1,4-dioxane;

DOI:10.1021/jm0506221

upstream raw materials:

{4-[(E)-2-(5-Nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-phenyl-acetic acid

2-(4-FORMYLPHENOXY)-2-PHENYLACETIC ACID

6-methyl-5-nitro-1,3-dipropyl-1H-pyrimidine-2,4-dione

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