4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylbenzenesulfonyl chloride

Base Information

Chemical Name:4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylbenzenesulfonyl chloride
CAS No.:1114592-14-1
Molecular Formula:C₂₂H₂₇ClN₄O₃S
Molecular Weight:463
Hs Code.:

Synonyms:4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylbenzenesulfonyl chloride

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Chemical Property of 4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylbenzenesulfonyl chloride

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Technology Process of 4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylbenzenesulfonyl chloride

There total 5 articles about 4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylbenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1114592-13-0
6-[cyclohexyl(cyclopropylmethyl)amino]-N-(2-methylphenyl)pyrimidine-4-carboxamide

: 1114592-14-1
4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylbenzenesulfonyl chloride

Guidance literature:: With chlorosulfonic acid; In dichloromethane; at -78 - 20 ℃; for 20h;

Reference yield:

: 263270-52-6
6-chloropyrimidine-4-carbonyl chloride

: 1114592-14-1
4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylbenzenesulfonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.42 h

2: N-ethyl-N,N-diisopropylamine / ethanol / 1 h / 160 °C

3: chlorosulfonic acid / dichloromethane / 20 h / -78 - 20 °C

With chlorosulfonic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

Reference yield:

: 1114592-12-9
6-chloro-N-(2-methylphenyl)pyrimidine-4-carboxamide

: 1114592-14-1
4-[({6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidin-4-yl}carbonyl)amino]-3-methylbenzenesulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 1 h / 160 °C

2: chlorosulfonic acid / dichloromethane / 20 h / -78 - 20 °C

With chlorosulfonic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;