[18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine

Base Information

Chemical Name:[18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine
CAS No.:1393331-67-3
Molecular Formula:C₂₃H₂₅BrF₂N₄O₂
Molecular Weight:506.38
Hs Code.:

Synonyms:[18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine

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Chemical Property of [18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine

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Technology Process of [18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine

There total 6 articles about [18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393331-68-4
C₂₁H₂₂BrFN₄O₂

: 113426-12-3
[(18)F]-2-fluoroethyltosylate

: 1393331-67-3
[18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine

Guidance literature:: C₂₁H₂₂BrFN₄O₂; With sodium hydroxide; In water; acetonitrile; at 90 ℃; Inert atmosphere;

[⁽¹⁸⁾F]-2-fluoroethyltosylate; In dimethyl sulfoxide; at 90 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.05.099

Reference yield:

: C₂₂H₁₅BrFN₃O₃

: 1393331-67-3
[18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran

2.1: potassium carbonate / tetrahydrofuran

3.1: trifluoroacetic acid / dichloromethane

4.1: sodium hydroxide / water; acetonitrile / 90 °C / Inert atmosphere

4.2: 0.33 h / 90 °C / Inert atmosphere

With potassium carbonate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2012.05.099

Reference yield:

: 116574-71-1,140645-19-8,140695-84-7,140695-85-8
tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate

: 1393331-67-3
[18F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 6 h

2.1: potassium carbonate / tetrahydrofuran

3.1: trifluoroacetic acid / dichloromethane

4.1: sodium hydroxide / water; acetonitrile / 90 °C / Inert atmosphere

4.2: 0.33 h / 90 °C / Inert atmosphere

With potassium carbonate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2012.05.099