(R)-tert-butoxycarbonylamino-(4-tert-butoxycarbonylamino-phenyl)-acetic acid

Base Information

• Chemical Name: (R)-tert-butoxycarbonylamino-(4-tert-butoxycarbonylamino-phenyl)-acetic acid
• CAS No.: 63633-71-6
• Molecular Formula: C₁₈H₂₆N₂O₆
• Molecular Weight: 366.414

Synonyms:(R)-tert-butoxycarbonylamino-(4-tert-butoxycarbonylamino-phenyl)-acetic acid

Chemical Property of (R)-tert-butoxycarbonylamino-(4-tert-butoxycarbonylamino-phenyl)-acetic acid

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Technology Process of (R)-tert-butoxycarbonylamino-(4-tert-butoxycarbonylamino-phenyl)-acetic acid

There total 1 articles about (R)-tert-butoxycarbonylamino-(4-tert-butoxycarbonylamino-phenyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

di-tert-butyl dicarbonate (24424-99-5) + amino-(4-amino-phenyl)-acetic acid ; dihydrochloride (7292-77-5,35619-38-6,69179-66-4,69608-78-2,101686-93-5,108272-93-1) → (R)-tert-butoxycarbonylamino-(4-tert-butoxycarbonylamino-phenyl)-acetic acid (63633-71-6,88197-41-5)

Guidance literature:

di-tert-butyl dicarbonate; amino-(4-amino-phenyl)-acetic acid ; dihydrochloride; With triethylamine; In tetrahydrofuran; water;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield: 82.0%

2-((2S,3S)-2-amino-3-phenyl-butyrylamino)-thiazole-4-carboxylic acid methyl ester (876755-70-3) + (R)-tert-butoxycarbonylamino-(4-tert-butoxycarbonylamino-phenyl)-acetic acid (63633-71-6,88197-41-5) → 2-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-2-(4-tert-butoxycarbonylamino-phenyl)-acetylamino]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester (876756-09-1)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

(R)-tert-butoxycarbonylamino-(4-tert-butoxycarbonylamino-phenyl)-acetic acid (63633-71-6,88197-41-5) + (6R,7S)-7-Amino-8-oxo-3-trifluoromethyl-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester; hydrochloride → (6R,7S)-7-[(R)-2-tert-Butoxycarbonylamino-2-(4-tert-butoxycarbonylamino-phenyl)-acetylamino]-8-oxo-3-trifluoromethyl-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester

Guidance literature:

With 4-methyl-morpholine; 1-chloro-3,5-dimethoxytriazine; In dichloromethane;

DOI:10.1016/S0960-894X(98)00204-2

upstream raw materials:

di-tert-butyl dicarbonate

amino-(4-amino-phenyl)-acetic acid ; dihydrochloride

Downstream raw materials:

2-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-2-(4-tert-butoxycarbonylamino-phenyl)-acetylamino]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester

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