trans-1-<1-(2-benzothienyl)-4-isothiocyanatocyclohexyl>piperidine hydrochloride

Base Information

• Chemical Name: trans-1-<1-(2-benzothienyl)-4-isothiocyanatocyclohexyl>piperidine hydrochloride
• CAS No.: 143603-62-7
• Molecular Formula: C₂₀H₂₄N₂S₂*ClH
• Molecular Weight: 393.017
• Mol file: 143603-62-7.mol

Synonyms:trans-1-<1-(2-benzothienyl)-4-isothiocyanatocyclohexyl>piperidine hydrochloride

Chemical Property of trans-1-<1-(2-benzothienyl)-4-isothiocyanatocyclohexyl>piperidine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-1-<1-(2-benzothienyl)-4-isothiocyanatocyclohexyl>piperidine hydrochloride

There total 3 articles about trans-1-<1-(2-benzothienyl)-4-isothiocyanatocyclohexyl>piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

thiophosgene (463-71-8) + trans-1-<4-amino-1-(2-benzothienyl)cyclohexyl>piperidine dihydrochloride (143603-44-5) → trans-1-<1-(2-benzothienyl)-4-isothiocyanatocyclohexyl>piperidine hydrochloride (143603-62-7)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; at 20 ℃; for 0.166667h;

DOI:10.1039/P19920001671

Reference yield:

trans-1-<4-azido-1-(2-benzothienyl)cyclohexyl>piperidine (143603-43-4) → trans-1-<1-(2-benzothienyl)-4-isothiocyanatocyclohexyl>piperidine hydrochloride (143603-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / conc. HCl, H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

2: 100 percent / sat. aq. NaHCO₃ / CHCl₃ / 0.17 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; chloroform;

DOI:10.1039/P19920001671

Reference yield:

Methanesulfonic acid 4-benzo[b]thiophen-2-yl-4-piperidin-1-yl-cyclohexyl ester (143603-42-3) → trans-1-<1-(2-benzothienyl)-4-isothiocyanatocyclohexyl>piperidine hydrochloride (143603-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / NaN₃ / dimethylformamide / 85 °C

2: 100 percent / conc. HCl, H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

3: 100 percent / sat. aq. NaHCO₃ / CHCl₃ / 0.17 h / 20 °C

With hydrogenchloride; sodium azide; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1039/P19920001671

upstream raw materials:

thiophosgene

trans-1-<4-amino-1-(2-benzothienyl)cyclohexyl>piperidine dihydrochloride

trans-1-<4-azido-1-(2-benzothienyl)cyclohexyl>piperidine

Methanesulfonic acid 4-benzo[b]thiophen-2-yl-4-piperidin-1-yl-cyclohexyl ester

Refernces