N-(3-fluoro-4-((6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Base Information

• Chemical Name: N-(3-fluoro-4-((6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• CAS No.: 849218-32-2
• Molecular Formula: C₃₄H₃₅F₂N₅O₅
• Molecular Weight: 631.679
• Mol file: 849218-32-2.mol

Synonyms:N-(3-fluoro-4-((6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Chemical Property of N-(3-fluoro-4-((6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-fluoro-4-((6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

There total 5 articles about N-(3-fluoro-4-((6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(3-((4-(2-fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6-methoxyquinolin-7-yl)oxy)propyl)piperazine-1-carboxylate → N-(3-fluoro-4-((6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (849218-32-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.chembiol.2019.06.003

Reference yield:

N'-(3-fluoro-4-hydroxyphenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (849217-58-9) → N-(3-fluoro-4-((6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (849218-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 3 h / 130 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.chembiol.2019.06.003

Reference yield:

tert-butyl 4-(3-((4-chloro-6-methoxyquinolin-7-yl)oxy)propyl)piperazine-1-carboxylate → N-(3-fluoro-4-((6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (849218-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 3 h / 130 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.chembiol.2019.06.003

upstream raw materials:

cyclopropane-1,1-dicarboxylic acid

N'-(3-fluoro-4-hydroxyphenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

4-(3-chloropropyl)piperazine-1-carboxylic acid tert-butyl ester