(4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-triphenyl-phosphonium bromide

Base Information

Chemical Name:(4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-triphenyl-phosphonium bromide
CAS No.:1072270-14-4
Molecular Formula:Br*C₂₇H₂₆ClN₃OP
Molecular Weight:554.854
Hs Code.:

Synonyms:(4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-triphenyl-phosphonium bromide

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Chemical Property of (4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-triphenyl-phosphonium bromide

Chemical Property:

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Technology Process of (4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-triphenyl-phosphonium bromide

There total 6 articles about (4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-triphenyl-phosphonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1072269-62-5
4-(2-bromomethyl-6-chloro-pyrimidin-4-yl)-morpholine

: 603-35-0
triphenylphosphine

: 1072270-14-4
(4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-triphenyl-phosphonium bromide

Guidance literature:: In toluene; at 111 ℃; for 2h;

Reference yield:

: 339016-18-1
4-chloro-6-(4-morpholinyl)-2-pyrimidinamine

: 1072270-14-4
(4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-triphenyl-phosphonium bromide

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide; diiodomethane; isopentyl nitrite / tetrahydrofuran / 1 h / 67 °C

2.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl acetamide / 0.75 h / 120 °C

3.1: hydrogenchloride / 3 h / 65 °C

4.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 2 h / 0 - 20 °C

4.2: 0.5 h

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 5 h / 20 °C

6.1: toluene / 2 h / 111 °C

With hydrogenchloride; sodium tetrahydroborate; copper(l) iodide; diiodomethane; carbon tetrabromide; triphenylphosphine; zinc; isopentyl nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; toluene;

Reference yield:

: 1072084-73-1
4-(6-chloro-2-iodopyrimidin-4-yl)morpholine

: 1072270-14-4
(4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-triphenyl-phosphonium bromide

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl acetamide / 0.75 h / 120 °C

2.1: hydrogenchloride / 3 h / 65 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 2 h / 0 - 20 °C

3.2: 0.5 h

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 5 h / 20 °C

5.1: toluene / 2 h / 111 °C

With hydrogenchloride; sodium tetrahydroborate; carbon tetrabromide; triphenylphosphine; zinc; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; toluene;