tert-Butyl 4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoate

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Chemical Name:tert-Butyl 4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoate
CAS No.:169134-86-5
Molecular Formula:C₂₈H₃₇N₅O₅
Molecular Weight:523.632
Hs Code.:

Synonyms:tert-Butyl 4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoate

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Chemical Property of tert-Butyl 4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoate

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Technology Process of tert-Butyl 4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoate

There total 7 articles about tert-Butyl 4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 151587-58-5
2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidine

: 149325-41-7
tert-Butyl 4-(2-bromoethyl)benzoate

: 84740-98-7
4-t-butyloxycarbonylstyrene

: 169134-86-5
tert-Butyl 4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; 1.) 0 deg C, 20 min, 2.) 0 deg C, 2 h;
DOI:10.1021/jo00129a040

Reference yield:

: 4214-85-1
2-amino-6-methyl-5-nitro-4(3H)-oxopyrimidine

: 169134-86-5
tert-Butyl 4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / CH₂Cl₂ / 5 h / Ambient temperature

2: 60 percent / NaH / dimethylformamide / 1.) r.t., 1 h, 2.) r.t., 12 h

3: 86 percent / dimethylformamide / 12 h / Ambient temperature

4: 94 percent / aq. Na₂S₂O₄ / tetrahydrofuran / 1 h / Ambient temperature

5: 10 percent / NaH / dimethylformamide / 1.) 0 deg C, 20 min, 2.) 0 deg C, 2 h

With sodium dithionite; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00129a040

Reference yield:

: 52062-92-7
4-(2-bromoethyl)benzoic acid

: 169134-86-5
tert-Butyl 4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / H₂SO₄ / CH₂Cl₂ / 24 h / Ambient temperature

2: 10 percent / NaH / dimethylformamide / 1.) 0 deg C, 20 min, 2.) 0 deg C, 2 h

With sulfuric acid; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00129a040