5-fluoro-2-(4-methylphenyl)benzoxazole

Base Information

• Chemical Name: 5-fluoro-2-(4-methylphenyl)benzoxazole
• CAS No.: 1207429-57-9
• Molecular Formula: C₁₄H₁₀FNO
• Molecular Weight: 227.238
• Mol file: 1207429-57-9.mol

Synonyms:5-fluoro-2-(4-methylphenyl)benzoxazole

Chemical Property of 5-fluoro-2-(4-methylphenyl)benzoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-fluoro-2-(4-methylphenyl)benzoxazole

There total 4 articles about 5-fluoro-2-(4-methylphenyl)benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

para-bromotoluene (106-38-7) + 5-fluorobenzo[d]oxazole (221347-71-3) → 5-fluoro-2-(4-methylphenyl)benzoxazole (1207429-57-9)

Guidance literature:

With (IPr)PdCl[2-(pyridin-2-yl)acetate]; lithium tert-butoxide; In N,N-dimethyl-formamide; at 130 ℃; for 12h; Reagent/catalyst;

DOI:10.1016/j.jorganchem.2018.07.029

Reference yield: 74.0%

3,3-diethyl-1-(4-methylphenyl)-1-triazene (36719-51-4) + 5-fluorobenzo[d]oxazole (221347-71-3) → 5-fluoro-2-(4-methylphenyl)benzoxazole (1207429-57-9)

Guidance literature:

With copper(l) iodide; palladium diacetate; In N,N-dimethyl-formamide; at 130 ℃; for 12h; Sealed tube;

DOI:10.1039/c9ob01883b

Reference yield: 71.0%

4-methylphenyl imidazolesulfonate (1139705-26-2) + 5-fluorobenzo[d]oxazole (221347-71-3) → 5-fluoro-2-(4-methylphenyl)benzoxazole (1207429-57-9)

Guidance literature:

With palladium diacetate; caesium carbonate; 1,2-bis-(diphenylphosphino)ethane; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 14h; Inert atmosphere;

DOI:10.1021/ol9028034

upstream raw materials:

4-methylphenyl imidazolesulfonate

5-fluorobenzo[d]oxazole

toluene-4-sulfonic acid hydrazide

para-bromotoluene

Refernces

• 1、 Liu, Can,Wang, Zhiming,Wang, Lei,Li, Pinhua,Zhang, Yicheng. "Palladium-catalyzed direct C2-arylation of azoles with aromatic triazenes". . p. 9209 - 9216. Retrieved 2019/11/05.
• 2、 Yuen, On Ying,So, Chau Ming,Wong, Wing Tak,Kwong, Fuk Yee. "Direct oxidative C-H arylation of benzoxazoles with arylsulfonyl hydrazides promoted by palladium complexes". supporting information. p. 2714 - 2718. Retrieved 2013/01/15.