diethyl N-<4-<<(3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazolin-9-yl)sulfonyl>amino>benzoyl>-L-glutamate

Base Information

• Chemical Name: diethyl N-<4-<<(3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazolin-9-yl)sulfonyl>amino>benzoyl>-L-glutamate
• CAS No.: 139988-29-7
• Molecular Formula: C₂₈H₃₀BrN₅O₈S
• Molecular Weight: 676.545
• Mol file: 139988-29-7.mol

Synonyms:diethyl N-<4-<<(3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazolin-9-yl)sulfonyl>amino>benzoyl>-L-glutamate

Chemical Property of diethyl N-<4-<<(3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazolin-9-yl)sulfonyl>amino>benzoyl>-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl N-<4-<<(3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazolin-9-yl)sulfonyl>amino>benzoyl>-L-glutamate

There total 2 articles about diethyl N-<4-<<(3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazolin-9-yl)sulfonyl>amino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

diethyl N-(p-aminobenzoyl)-L-glutamate (13726-52-8) + 3-amino-8-bromo-5,6-dihydrobenzo[f]quinazolin-1(2H)-one-9-sulfonyl chloride (139988-23-1) → diethyl N-<4-<<(3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazolin-9-yl)sulfonyl>amino>benzoyl>-L-glutamate (139988-29-7)

Guidance literature:

at 175 ℃; for 1.33333h;

DOI:10.1021/jm00074a030

Reference yield:

3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazoline (139986-48-4) → diethyl N-<4-<<(3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazolin-9-yl)sulfonyl>amino>benzoyl>-L-glutamate (139988-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / ClSO₃H / Ambient temperature

2: 26 percent / 1.33 h / 175 °C

With chlorosulfonic acid;

DOI:10.1021/jm00074a030

Reference yield:

diethyl N-<4-<<(3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazolin-9-yl)sulfonyl>amino>benzoyl>-L-glutamate (139988-29-7) → diethyl N-(4-(((3-amino-1,2,5,6-tetrahydro-1-oxobenzo[f]quinazolin-9-yl)sulfonyl)amino)benzoyl)-L-glutamate (139988-30-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 35h; Ambient temperature;

DOI:10.1021/jm00074a030

upstream raw materials:

diethyl N-(p-aminobenzoyl)-L-glutamate

3-amino-8-bromo-5,6-dihydrobenzo[f]quinazolin-1(2H)-one-9-sulfonyl chloride

3-amino-8-bromo-1,2,5,6-tetrahydro-1-oxobenzoquinazoline

Downstream raw materials:

diethyl N-(4-(((3-amino-1,2,5,6-tetrahydro-1-oxobenzo[f]quinazolin-9-yl)sulfonyl)amino)benzoyl)-L-glutamate