(S)-2-Benzenesulfonylamino-3-({4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carbonyl)-amino)-propionic Acid tert-butyl Ester

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Chemical Name:(S)-2-Benzenesulfonylamino-3-({4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carbonyl)-amino)-propionic Acid tert-butyl Ester
CAS No.:262278-59-1
Molecular Formula:C₃₀H₃₄N₆O₇S
Molecular Weight:622.702
Hs Code.:

Synonyms:(S)-2-Benzenesulfonylamino-3-({4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carbonyl)-amino)-propionic Acid tert-butyl Ester

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Chemical Property of (S)-2-Benzenesulfonylamino-3-({4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carbonyl)-amino)-propionic Acid tert-butyl Ester

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Technology Process of (S)-2-Benzenesulfonylamino-3-({4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carbonyl)-amino)-propionic Acid tert-butyl Ester

There total 9 articles about (S)-2-Benzenesulfonylamino-3-({4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carbonyl)-amino)-propionic Acid tert-butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 262278-58-0
4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carboxylic acid

: tert-butyl (2S)-N-benzenesulfonyl-2,3-diaminopropionate hydrochloride

: 262278-59-1
(S)-2-Benzenesulfonylamino-3-({4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carbonyl)-amino)-propionic Acid tert-butyl Ester

Guidance literature:: With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 2,3,5-trimethyl-pyridine; methanol;

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 262278-59-1
(S)-2-Benzenesulfonylamino-3-({4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carbonyl)-amino)-propionic Acid tert-butyl Ester

Guidance literature:: Multi-step reaction with 10 steps

1: NaH / ammonium chloride; dimethyl sulfoxide

2: m-chloroperoxybenzoic acid; acetic anhydride / methanol; dichloromethane; sodium hydrogencarbonate; acetone

3: manganese dioxide; potassium carbonate / methanol; dichioromethane; dichloromethane

4: PTSA / tetrahydrofuran; NaH; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; ethyl acetate

5: palladium-carbon / 1,4-dioxane; methanol

6: caesium carbonate / ethyl acetate; N,N-dimethyl-formamide

7: trifluoroacetic acid / dichloromethane

8: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide

10: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / 2,3,5-trimethyl-pyridine; methanol

With manganese dioxide; m-chloroperoxybenzoic acid; NaH; acetic anhydride; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; PTSA; palladium-carbon; In tetrahydrofuran; 1,4-dioxane; 2,3,5-trimethyl-pyridine; methanol; dichioromethane; NaH; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; ammonium chloride; sodium hydrogencarbonate; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 59781-10-1
2-acetoxymethyl-5-benzyloxy pyridine

: 262278-59-1
(S)-2-Benzenesulfonylamino-3-({4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carbonyl)-amino)-propionic Acid tert-butyl Ester

Guidance literature:: Multi-step reaction with 8 steps

1: manganese dioxide; potassium carbonate / methanol; dichioromethane; dichloromethane

2: PTSA / tetrahydrofuran; NaH; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; ethyl acetate

3: palladium-carbon / 1,4-dioxane; methanol

4: caesium carbonate / ethyl acetate; N,N-dimethyl-formamide

5: trifluoroacetic acid / dichloromethane

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide

8: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / 2,3,5-trimethyl-pyridine; methanol

With manganese dioxide; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; PTSA; palladium-carbon; In tetrahydrofuran; 1,4-dioxane; 2,3,5-trimethyl-pyridine; methanol; dichioromethane; NaH; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;