1-(2-(4-chlorobenzyloxy)-2-(2,4-difluorophenyl)ethyl)-2-thiomethoxy-4-nitro-1H-imidazole

Base Information

Chemical Name:1-(2-(4-chlorobenzyloxy)-2-(2,4-difluorophenyl)ethyl)-2-thiomethoxy-4-nitro-1H-imidazole
CAS No.:1283135-64-7
Molecular Formula:C₁₉H₁₆ClF₂N₃O₃S
Molecular Weight:439.87
Hs Code.:

Synonyms:1-(2-(4-chlorobenzyloxy)-2-(2,4-difluorophenyl)ethyl)-2-thiomethoxy-4-nitro-1H-imidazole

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Chemical Property of 1-(2-(4-chlorobenzyloxy)-2-(2,4-difluorophenyl)ethyl)-2-thiomethoxy-4-nitro-1H-imidazole

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Technology Process of 1-(2-(4-chlorobenzyloxy)-2-(2,4-difluorophenyl)ethyl)-2-thiomethoxy-4-nitro-1H-imidazole

There total 3 articles about 1-(2-(4-chlorobenzyloxy)-2-(2,4-difluorophenyl)ethyl)-2-thiomethoxy-4-nitro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1283135-33-0
2-bromo-1-(2-(4-chlorobenzyloxy)-2-(2,4-difluorophenyl)ethyl)-4-nitro-1H-imidazole

: 5188-07-8
sodium thiomethoxide

: 1283135-64-7
1-(2-(4-chlorobenzyloxy)-2-(2,4-difluorophenyl)ethyl)-2-thiomethoxy-4-nitro-1H-imidazole

Guidance literature:: In methanol; at 0 ℃;
DOI:10.1016/j.bmcl.2010.12.128

Reference yield:

: 1283135-22-7
2-(2-bromo-4-nitro-1H-imidazol-1-yl)-1-(2,4-difluorophenyl)ethanol

: 1283135-64-7
1-(2-(4-chlorobenzyloxy)-2-(2,4-difluorophenyl)ethyl)-2-thiomethoxy-4-nitro-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / -78 - 20 °C / Inert atmosphere

2: methanol / 0 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2010.12.128

Reference yield:

: 51336-96-0,900508-66-9
2-chloro-1-(2’,4’-difluorophenyl)ethanol

: 1283135-64-7
1-(2-(4-chlorobenzyloxy)-2-(2,4-difluorophenyl)ethyl)-2-thiomethoxy-4-nitro-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: tetra-(n-butyl)ammonium iodide; potassium carbonate / ethanol / Reflux

2: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / -78 - 20 °C / Inert atmosphere

3: methanol / 0 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; In methanol; ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2010.12.128