[3-oxo-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,3-dihydroindazol-2-yl]acetic acid

Base Information

Chemical Name:[3-oxo-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,3-dihydroindazol-2-yl]acetic acid
CAS No.:1299466-98-0
Molecular Formula:C₂₂H₁₅F₃N₂O₄
Molecular Weight:428.367
Hs Code.:

Synonyms:[3-oxo-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,3-dihydroindazol-2-yl]acetic acid

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Chemical Property of [3-oxo-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,3-dihydroindazol-2-yl]acetic acid

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Technology Process of [3-oxo-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,3-dihydroindazol-2-yl]acetic acid

There total 5 articles about [3-oxo-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,3-dihydroindazol-2-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1299466-99-1
C₃₀H₃₁F₃N₂O₇

: 1299466-98-0
[3-oxo-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,3-dihydroindazol-2-yl]acetic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; for 1.5h; Reflux;
DOI:10.1016/j.bmcl.2013.03.049

Reference yield:

: 1298129-65-3
2',4',5'-trifluoro-biphenyl-4-ol

: 1299466-98-0
[3-oxo-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,3-dihydroindazol-2-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: caesium carbonate; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate / toluene / 5 h / 110 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / water; tetrahydrofuran / 1.5 h / Reflux

With hydrogenchloride; palladium diacetate; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1016/j.bmcl.2013.03.049

Reference yield:

: 750585-90-1
methyl 2-bromo-3-(bromomethyl)benzoate

: 1299466-98-0
[3-oxo-7-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)-1,3-dihydroindazol-2-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: caesium carbonate; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate / toluene / 5 h / 110 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / water; tetrahydrofuran / 1.5 h / Reflux

With hydrogenchloride; palladium diacetate; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1016/j.bmcl.2013.03.049