1-[(Z)-2'-bromo-3'-(3'',4''-dimethoxyphenyl)prop-2'-enyl]-2-chloromethylpiperidine

Base Information

Chemical Name:1-[(Z)-2'-bromo-3'-(3'',4''-dimethoxyphenyl)prop-2'-enyl]-2-chloromethylpiperidine
CAS No.:741719-73-3
Molecular Formula:C₁₇H₂₃BrClNO₂
Molecular Weight:388.732
Hs Code.:

Synonyms:1-[(Z)-2'-bromo-3'-(3'',4''-dimethoxyphenyl)prop-2'-enyl]-2-chloromethylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(Z)-2'-bromo-3'-(3'',4''-dimethoxyphenyl)prop-2'-enyl]-2-chloromethylpiperidine

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Technology Process of 1-[(Z)-2'-bromo-3'-(3'',4''-dimethoxyphenyl)prop-2'-enyl]-2-chloromethylpiperidine

There total 6 articles about 1-[(Z)-2'-bromo-3'-(3'',4''-dimethoxyphenyl)prop-2'-enyl]-2-chloromethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 741719-59-5
{1-[(Z)-2'-bromo-3'-(3'',4''-dimethoxyphenyl)prop-2'-enyl]piperidin-2-yl}methanol

: 741719-73-3
1-[(Z)-2'-bromo-3'-(3'',4''-dimethoxyphenyl)prop-2'-enyl]-2-chloromethylpiperidine

Guidance literature:: With dmap; p-toluenesulfonyl chloride; In dichloromethane; at 18 ℃; for 16h;
DOI:10.1071/CH03292

Reference yield:

: 741719-60-8
4-(2',2'-dibromocyclopropyl)-1,2-dimethoxybenzene

: 741719-73-3
1-[(Z)-2'-bromo-3'-(3'',4''-dimethoxyphenyl)prop-2'-enyl]-2-chloromethylpiperidine

Guidance literature:: Multi-step reaction with 5 steps

1: AcOH / 16 h / Heating

2: 99 percent / K₂CO₃ / methanol / 2 h / 18 °C

3: 69 percent / N-chlorosuccinimide; Me₂S / CH₂Cl₂ / 17.5 h / 0 - 18 °C

4: 98 percent / Et₃N / dimethylformamide / 16 h / 70 °C

5: 99 percent / p-TsCl; DMAP / CH₂Cl₂ / 16 h / 18 °C

With dmap; N-chloro-succinimide; dimethylsulfide; potassium carbonate; acetic acid; triethylamine; p-toluenesulfonyl chloride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1071/CH03292

Reference yield:

: 741719-72-2
(Z)-4-(2'-bromo-3'-chloroprop-1'-enyl)-1,2-dimethoxybenzene

: 741719-73-3
1-[(Z)-2'-bromo-3'-(3'',4''-dimethoxyphenyl)prop-2'-enyl]-2-chloromethylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / Et₃N / dimethylformamide / 16 h / 70 °C

2: 99 percent / p-TsCl; DMAP / CH₂Cl₂ / 16 h / 18 °C

With dmap; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1071/CH03292