3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Base Information

Chemical Name:3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide
CAS No.:1393900-44-1
Molecular Formula:C₂₅H₂₇F₃N₆O
Molecular Weight:484.524
Hs Code.:

Synonyms:3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

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Chemical Property of 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

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Technology Process of 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

There total 12 articles about 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1393900-96-3
3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoic acid

: 1393900-44-1
3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Guidance literature:: With ammonium hydroxide; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 618-51-9
3-Iodobenzoic acid

: 1393900-44-1
3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap / dichloromethane / 64 h / 20 °C / Inert atmosphere

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 0.17 h / Inert atmosphere

2.2: 18 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.42 h / 120 °C / microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / Dichlorofluoromethane / 16 h / 0 - 20 °C

7.1: toluene-4-sulfonic acid / 1,4-dioxane / 0.5 h / 140 - 150 °C / microwave irradiation

8.1: trifluoroacetic acid / dichloromethane / 1.58 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; ammonium hydroxide; HATU / N,N-dimethyl-formamide / 20 °C

With dmap; ammonium hydroxide; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; Dichlorofluoromethane; N,N-dimethyl-formamide;

Reference yield:

: 173406-17-2
tert-butyl 3-iodobenzoate

: 1393900-44-1
3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 0.17 h / Inert atmosphere

1.2: 18 h

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.42 h / 120 °C / microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / Dichlorofluoromethane / 16 h / 0 - 20 °C

6.1: toluene-4-sulfonic acid / 1,4-dioxane / 0.5 h / 140 - 150 °C / microwave irradiation

7.1: trifluoroacetic acid / dichloromethane / 1.58 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; ammonium hydroxide; HATU / N,N-dimethyl-formamide / 20 °C

With ammonium hydroxide; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; Dichlorofluoromethane; N,N-dimethyl-formamide;