1-(7-Chloroisoquinolin-3-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Base Information

Chemical Name:1-(7-Chloroisoquinolin-3-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol
CAS No.:1416805-63-4
Molecular Formula:C₁₉H₁₂ClF₄N₅O
Molecular Weight:437.784
Hs Code.:

Synonyms:1-(7-Chloroisoquinolin-3-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

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Chemical Property of 1-(7-Chloroisoquinolin-3-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

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Technology Process of 1-(7-Chloroisoquinolin-3-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

There total 11 articles about 1-(7-Chloroisoquinolin-3-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 288-94-8
1H-tetrazole

: 1416806-11-5
C₁₈H₁₀ClF₄NO

: 1416805-63-4
1-(7-Chloroisoquinolin-3-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 65 ℃;

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1416805-63-4
1-(7-Chloroisoquinolin-3-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium cyanide / water; methanol / 20 - 70 °C

2.1: 6 h / 120 °C / Inert atmosphere

3.1: ammonia / dichloromethane; water / 0.5 h / -25 °C / Inert atmosphere

4.1: copper(ll) sulfate pentahydrate / ethanol; water / 0.5 h / Inert atmosphere; Reflux

5.1: trifluoroacetic acid / ethanol / Inert atmosphere; Reflux

6.1: trifluoroacetic acid / dichloromethane / 3 h / Inert atmosphere; Reflux

7.1: sodium nitrite; hydrogen bromide / water / 1.25 h / 0 °C

8.1: bronze powder / dimethyl sulfoxide / 16 h / Inert atmosphere

9.1: n-butyllithium / hexane; diethyl ether / -78 °C / Inert atmosphere

9.2: 1.25 h / -78 - 20 °C / Inert atmosphere

10.1: diethyl ether / 4 h / 0 - 20 °C

11.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C

With sodium cyanide; bronze powder; n-butyllithium; copper(ll) sulfate pentahydrate; ammonia; hydrogen bromide; potassium carbonate; trifluoroacetic acid; sodium nitrite; trifluoroacetic acid; In methanol; diethyl ether; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 135737-05-2
(4-Chloro-phenyl)-(cyanomethyl-methyl-amino)-acetonitrile

: 1416805-63-4
1-(7-Chloroisoquinolin-3-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 6 h / 120 °C / Inert atmosphere

2.1: ammonia / dichloromethane; water / 0.5 h / -25 °C / Inert atmosphere

3.1: copper(ll) sulfate pentahydrate / ethanol; water / 0.5 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / ethanol / Inert atmosphere; Reflux

5.1: trifluoroacetic acid / dichloromethane / 3 h / Inert atmosphere; Reflux

6.1: sodium nitrite; hydrogen bromide / water / 1.25 h / 0 °C

7.1: bronze powder / dimethyl sulfoxide / 16 h / Inert atmosphere

8.1: n-butyllithium / hexane; diethyl ether / -78 °C / Inert atmosphere

8.2: 1.25 h / -78 - 20 °C / Inert atmosphere

9.1: diethyl ether / 4 h / 0 - 20 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C

With bronze powder; n-butyllithium; copper(ll) sulfate pentahydrate; ammonia; hydrogen bromide; potassium carbonate; trifluoroacetic acid; sodium nitrite; trifluoroacetic acid; In diethyl ether; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;