Technology Process of (-)-1-{(1'R,2'S,3'R,4'S)-4'-[(R)-methoxycarbonyl(benzyloxycarbonylamino)methyl]-2',3'-dihydroxycyclopentyl}uracil
There total 7 articles about (-)-1-{(1'R,2'S,3'R,4'S)-4'-[(R)-methoxycarbonyl(benzyloxycarbonylamino)methyl]-2',3'-dihydroxycyclopentyl}uracil which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; tert-butyl alcohol;
at 20 ℃;
DOI:10.1021/jo0496796
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / NaOAc; Pd(OAc)2; PPh3 / tetrahydrofuran / 20 °C
2: 879 mg / L-tartaric acid; NaBH4; TiCl3 / HCl; NaOH / H2O; methanol / 4 h / pH 7.8
3: 93 percent / NaHCO3 / tetrahydrofuran; H2O
4: trifluoroacetic acid / CH2Cl2 / 0.75 h / cooling
5: tetrahydrofuran; benzene
6: sulfuric acid / methanol / Heating
7: 37 percent / N-methylmorpholine N-oxide monohydrate; OsO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 20 °C
With
palladium diacetate; sodium tetrahydroborate; osmium(VIII) oxide; titanium(III) chloride; L-Tartaric acid; sulfuric acid; sodium acetate; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triphenylphosphine; trifluoroacetic acid;
hydrogenchloride; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1021/jo0496796
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 879 mg / L-tartaric acid; NaBH4; TiCl3 / HCl; NaOH / H2O; methanol / 4 h / pH 7.8
2: 93 percent / NaHCO3 / tetrahydrofuran; H2O
3: trifluoroacetic acid / CH2Cl2 / 0.75 h / cooling
4: tetrahydrofuran; benzene
5: sulfuric acid / methanol / Heating
6: 37 percent / N-methylmorpholine N-oxide monohydrate; OsO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 20 °C
With
sodium tetrahydroborate; osmium(VIII) oxide; titanium(III) chloride; L-Tartaric acid; sulfuric acid; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; trifluoroacetic acid;
hydrogenchloride; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1021/jo0496796