C₄₂H₃₅ClN₄O₄

Base Information

• Chemical Name: C₄₂H₃₅ClN₄O₄
• CAS No.: 1312579-08-0
• Molecular Formula: C₄₂H₃₅ClN₄O₄
• Molecular Weight: 695.217
• Mol file: 1312579-08-0.mol

Synonyms:C₄₂H₃₅ClN₄O₄

Chemical Property of C₄₂H₃₅ClN₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₃₅ClN₄O₄

There total 11 articles about C₄₂H₃₅ClN₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

C37H31BrClN3O4 (1312579-07-9) + 3-pyridylboronic acid (1692-25-7) → C42H35ClN4O4 (1312579-08-0)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 140 ℃; for 1h; microwave irradiation;

Reference yield:

phenylmethyl 1-piperazinecarboxylate (31166-44-6) → C42H35ClN4O4 (1312579-08-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triethylamine / N,N-dimethyl-formamide / 15 h / 80 °C

2.1: 2,2,6,6-tetramethyl-piperidine; TurboGrignard / tetrahydrofuran / 2 h / -20 °C

2.2: 2 h / -20 °C

3.1: zinc; acetic acid / 2 h / 20 °C

4.1: trifluoroacetic acid; triethylsilane / dichloromethane / 15 h / 20 °C

5.1: trimethylaluminum / toluene; hexanes / 3 h / 20 - 80 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 15 h / 20 °C

7.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1 h / 140 °C / microwave irradiation

With 2,2,6,6-tetramethyl-piperidine; triethylsilane; TurboGrignard; trimethylaluminum; sodium hydride; sodium carbonate; acetic acid; triethylamine; trifluoroacetic acid; zinc; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexanes; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

C32H30ClN3O8 (1357089-48-5) → C42H35ClN4O4 (1312579-08-0)

Guidance literature:

Multi-step reaction with 5 steps

1: zinc; acetic acid / 2 h / 20 °C

2: trifluoroacetic acid; triethylsilane / dichloromethane / 15 h / 20 °C

3: trimethylaluminum / toluene; hexanes / 3 h / 20 - 80 °C

4: sodium hydride / tetrahydrofuran; mineral oil / 15 h / 20 °C

5: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1 h / 140 °C / microwave irradiation

With triethylsilane; trimethylaluminum; sodium hydride; sodium carbonate; acetic acid; trifluoroacetic acid; zinc; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexanes; 1,2-dimethoxyethane; dichloromethane; water; toluene; mineral oil;

upstream raw materials:

1-Bromo-2-bromomethyl-benzene

C₃₇H₃₁BrClN₃O₄

3-pyridylboronic acid

phenylmethyl 1-piperazinecarboxylate

Downstream raw materials:

C₃₄H₂₉ClN₄O₂