methyl 5-amino-2-(methoxymethyl)-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate

Base Information

Chemical Name:methyl 5-amino-2-(methoxymethyl)-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate
CAS No.:1365033-52-8
Molecular Formula:C₁₇H₂₁N₃O₄
Molecular Weight:331.371
Hs Code.:

Synonyms:methyl 5-amino-2-(methoxymethyl)-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 5-amino-2-(methoxymethyl)-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate

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Technology Process of methyl 5-amino-2-(methoxymethyl)-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate

There total 5 articles about methyl 5-amino-2-(methoxymethyl)-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365033-44-8
methyl 2-(methoxymethyl)-5-nitro-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate

: 1365033-52-8
methyl 5-amino-2-(methoxymethyl)-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate

Guidance literature:: With iron; ammonium chloride; In tetrahydrofuran; methanol; water; at 70 ℃; for 4.5h;

Reference yield:

: 842167-67-3
1-bromo-4-fluoro-2-(methoxymethyl)benzene

: 1365033-52-8
methyl 5-amino-2-(methoxymethyl)-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / dimethyl sulfoxide

2: sulfuric acid; potassium nitrate / 4.5 h / -10 °C

3: triethylamine / acetonitrile / 5.5 h / 70 °C

4: ammonium chloride; iron / water; methanol; tetrahydrofuran / 4.5 h / 70 °C

With sulfuric acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; iron; ammonium chloride; potassium nitrate; triethylamine; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1243164-94-4
methyl 4-fluoro-2-(methoxymethyl)benzoate

: 1365033-52-8
methyl 5-amino-2-(methoxymethyl)-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; potassium nitrate / 4.5 h / -10 °C

2: triethylamine / acetonitrile / 5.5 h / 70 °C

3: ammonium chloride; iron / water; methanol; tetrahydrofuran / 4.5 h / 70 °C

With sulfuric acid; iron; ammonium chloride; potassium nitrate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile;