5-(N-tert-butyloxycarbonyl-3-aminopropoxy)-N₁,N₃-bis(3-{[(6-{[[di(2-pyridinyl)methyl](2-pyridinylmethyl)amino]methyl}-3-pyridinyl)carbonyl]amino}propyl)isophthalamide

Base Information

• Chemical Name: 5-(N-tert-butyloxycarbonyl-3-aminopropoxy)-N₁,N₃-bis(3-{[(6-{[[di(2-pyridinyl)methyl](2-pyridinylmethyl)amino]methyl}-3-pyridinyl)carbonyl]amino}propyl)isophthalamide
• CAS No.: 1141722-27-1
• Molecular Formula: C₇₀H₇₅N₁₅O₇
• Molecular Weight: 1238.46

Synonyms:5-(N-tert-butyloxycarbonyl-3-aminopropoxy)-N₁,N₃-bis(3-{[(6-{[[di(2-pyridinyl)methyl](2-pyridinylmethyl)amino]methyl}-3-pyridinyl)carbonyl]amino}propyl)isophthalamide

Chemical Property of 5-(N-tert-butyloxycarbonyl-3-aminopropoxy)-N₁,N₃-bis(3-{[(6-{[[di(2-pyridinyl)methyl](2-pyridinylmethyl)amino]methyl}-3-pyridinyl)carbonyl]amino}propyl)isophthalamide

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Technology Process of 5-(N-tert-butyloxycarbonyl-3-aminopropoxy)-N₁,N₃-bis(3-{[(6-{[[di(2-pyridinyl)methyl](2-pyridinylmethyl)amino]methyl}-3-pyridinyl)carbonyl]amino}propyl)isophthalamide

There total 1 articles about 5-(N-tert-butyloxycarbonyl-3-aminopropoxy)-N₁,N₃-bis(3-{[(6-{[[di(2-pyridinyl)methyl](2-pyridinylmethyl)amino]methyl}-3-pyridinyl)carbonyl]amino}propyl)isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-{3-[(tert-butoxycarbonyl)amino]propoxy}isophthalic acid (1141722-23-7) + N-(3-aminopropyl)-6-(((di-pyridin-2-yl-methyl)pyridin-2-ylmethylamino)methyl)nicotinamide (321907-45-3) → 5-(N-tert-butyloxycarbonyl-3-aminopropoxy)-N1,N3-bis(3-{[(6-{[[di(2-pyridinyl)methyl](2-pyridinylmethyl)amino]methyl}-3-pyridinyl)carbonyl]amino}propyl)isophthalamide (1141722-27-1)

Guidance literature:

With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1002/chem.200801409

Reference yield: 43.0%

5-(N-tert-butyloxycarbonyl-3-aminopropoxy)-N1,N3-bis(3-{[(6-{[[di(2-pyridinyl)methyl](2-pyridinylmethyl)amino]methyl}-3-pyridinyl)carbonyl]amino}propyl)isophthalamide (1141722-27-1) → 5-(3-aminopropoxy)-N1,N3-bis(3-{[(6-{[[di(2-pyridinyl)methyl](2-pyridinylmethyl)amino]methyl}-3-pyridinyl)carbonyl]amino}propyl)isophthalamide (1141722-29-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1002/chem.200801409

upstream raw materials:

5-{3-[(tert-butoxycarbonyl)amino]propoxy}isophthalic acid

N-(3-aminopropyl)-6-(((di-pyridin-2-yl-methyl)pyridin-2-ylmethylamino)methyl)nicotinamide

Downstream raw materials:

5-(3-aminopropoxy)-N₁,N₃-bis(3-{[(6-{[[di(2-pyridinyl)methyl](2-pyridinylmethyl)amino]methyl}-3-pyridinyl)carbonyl]amino}propyl)isophthalamide

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