3-[2-fluoro-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-(2-hydroxyethyl)-1-phenylurea

Base Information

Chemical Name:3-[2-fluoro-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-(2-hydroxyethyl)-1-phenylurea
CAS No.:1219727-83-9
Molecular Formula:C₂₂H₂₀FN₅O₂
Molecular Weight:405.432
Hs Code.:

Synonyms:3-[2-fluoro-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-(2-hydroxyethyl)-1-phenylurea

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Chemical Property of 3-[2-fluoro-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-(2-hydroxyethyl)-1-phenylurea

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Technology Process of 3-[2-fluoro-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-(2-hydroxyethyl)-1-phenylurea

There total 3 articles about 3-[2-fluoro-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-(2-hydroxyethyl)-1-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₆BFN₂O₄

: 1618-36-6
4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine

: 1219727-83-9
3-[2-fluoro-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-(2-hydroxyethyl)-1-phenylurea

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 95 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2015.10.041

Reference yield:

: 88112-75-8
4-bromo-2-fluorophenyl isocyanate

: 1219727-83-9
3-[2-fluoro-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-(2-hydroxyethyl)-1-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 2 h

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 95 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmc.2015.10.041

Reference yield:

: 122-98-5
2-Anilinoethanol

: 1219727-83-9
3-[2-fluoro-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-(2-hydroxyethyl)-1-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 2 h

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 95 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmc.2015.10.041