(S)-1-((7S,9S,10R)-10-Dibenzylamino-3-hydroxy-9-methoxy-7-triisopropylsilanyloxy-undecanoyl)-piperidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(S)-1-((7S,9S,10R)-10-Dibenzylamino-3-hydroxy-9-methoxy-7-triisopropylsilanyloxy-undecanoyl)-piperidine-2-carboxylic acid methyl ester
CAS No.:186957-68-6
Molecular Formula:C₄₂H₆₈N₂O₆Si
Molecular Weight:725.097
Hs Code.:

Synonyms:(S)-1-((7S,9S,10R)-10-Dibenzylamino-3-hydroxy-9-methoxy-7-triisopropylsilanyloxy-undecanoyl)-piperidine-2-carboxylic acid methyl ester

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Chemical Property of (S)-1-((7S,9S,10R)-10-Dibenzylamino-3-hydroxy-9-methoxy-7-triisopropylsilanyloxy-undecanoyl)-piperidine-2-carboxylic acid methyl ester

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Technology Process of (S)-1-((7S,9S,10R)-10-Dibenzylamino-3-hydroxy-9-methoxy-7-triisopropylsilanyloxy-undecanoyl)-piperidine-2-carboxylic acid methyl ester

There total 7 articles about (S)-1-((7S,9S,10R)-10-Dibenzylamino-3-hydroxy-9-methoxy-7-triisopropylsilanyloxy-undecanoyl)-piperidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 35677-83-9,41994-45-0,43041-11-8,90710-04-6
methyl (S)-pipecolinate

: Lithium; (7S,9S,10R)-10-dibenzylamino-3-hydroxy-9-methoxy-7-triisopropylsilanyloxy-undecanoate

: 186957-68-6
(S)-1-((7S,9S,10R)-10-Dibenzylamino-3-hydroxy-9-methoxy-7-triisopropylsilanyloxy-undecanoyl)-piperidine-2-carboxylic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 25 ℃; for 12h;
DOI:10.1246/cl.1997.9

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 186957-68-6
(S)-1-((7S,9S,10R)-10-Dibenzylamino-3-hydroxy-9-methoxy-7-triisopropylsilanyloxy-undecanoyl)-piperidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

2: 87 percent / HF / pyridine; tetrahydrofuran / 1.5 h / Ambient temperature

3: 96 percent / (COCl)2, DMSO, Et₃N / CH₂Cl₂ / 1 h / -78 - 0 °C

4: 87 percent / LDA / tetrahydrofuran / 1.5 h / -78 °C

5: 74 percent / LiOH / tetrahydrofuran; methanol; H₂O / 1.5 h / Ambient temperature

6: 86 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole / CH₂Cl₂ / 12 h / 0 - 25 °C

With 2,6-dimethylpyridine; lithium hydroxide; oxalyl dichloride; hydrogen fluoride; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; pyridine; methanol; dichloromethane; water;
DOI:10.1246/cl.1997.9

Reference yield:

: 111060-63-0,121010-18-2,129286-74-4,120205-96-1
(R)-2-(dibenzylamino)propanal

: 186957-68-6
(S)-1-((7S,9S,10R)-10-Dibenzylamino-3-hydroxy-9-methoxy-7-triisopropylsilanyloxy-undecanoyl)-piperidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / LDA / tetrahydrofuran / 1.5 h / -78 - 25 °C

2: 71 percent / Ag₂O, 4 A MS, / diethyl ether / 48 h / Heating

3: 58 percent / red-Al / diethyl ether / 0.25 h / 0 °C

4: 98 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

5: 87 percent / HF / pyridine; tetrahydrofuran / 1.5 h / Ambient temperature

6: 96 percent / (COCl)2, DMSO, Et₃N / CH₂Cl₂ / 1 h / -78 - 0 °C

7: 87 percent / LDA / tetrahydrofuran / 1.5 h / -78 °C

8: 74 percent / LiOH / tetrahydrofuran; methanol; H₂O / 1.5 h / Ambient temperature

9: 86 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole / CH₂Cl₂ / 12 h / 0 - 25 °C

With 2,6-dimethylpyridine; lithium hydroxide; oxalyl dichloride; hydrogen fluoride; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; silver(l) oxide; lithium diisopropyl amide; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; water;
DOI:10.1246/cl.1997.9